Is there any relationship between the attenuation of cerebral ischemia-reperfusion injury and serum YAP-1 levels?

Basit Öğe Kaydı
dc.contributor.authorTanbek, Kevser
dc.contributor.authorSandal, Süleyman
dc.date.accessioned2024-08-04T19:42:45Z
dc.date.available2024-08-04T19:42:45Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Cerebral ischemia (CI) is one of the leading causes of death worldwide. Due to the long and costly treatment process after ischemia and the need for lifelong patient care, studies in this field are important. Explaining the mechanism of damage is valuable in terms of developing preventive applications in risky persons and accelerating the treatment processes of sick patients. The aim of this study was to evaluate the relationship between serum yes-associated protein 1 (YAP-1) level, an antiapoptotic marker, and cerebral ischemia-reperfusion (CI/R) injury. Materials and Methods: Wistar Albino adult (10 weeks old, 280-300 g) male rats were randomly assigned to Sham, CI, Asp+CI, and CI+Asp, with 24-hours and 7-day reperfusion periods (n=8). CI was created using the intra-arterial filament technique during 60 minutes, Asprosin (Asp) (1 µg/kg/day) injections were applied 3 days before or 3 days during of 24h and 7 days reperfusion. YAP- l levels were measured using customary ELISA kits. The Kruskal-Wallis test was used to compare differences between groups. p<0.05 was considered statistically significant. Results: The decrease in YAP-1 in the CI groups is statistically significant (p<0.05) compared to the sham group. The increase in YAP-1 levels in Asp groups compared with CI group is statistically significant (p<0.05). Conclusion: The serum YAP-1 levels decreased due to CI/R injury. Asp, which is known to be effective in the apoptosis pathway, increased YAP-1 levels when used for protective and therapeutic purposes against CI/R injury.en_US
dc.identifier.doi10.5455/annalsmedres.2024.02.047
dc.identifier.endpage264en_US
dc.identifier.issn2636-7688
dc.identifier.issue3en_US
dc.identifier.startpage260en_US
dc.identifier.trdizinid1229265en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2024.02.047
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1229265
dc.identifier.urihttps://hdl.handle.net/11616/88646
dc.identifier.volume31en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleIs there any relationship between the attenuation of cerebral ischemia-reperfusion injury and serum YAP-1 levels?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu