Curcumin, myrecen and cineol modulate the percentage of lymphocyte subsets altered by 2,3,7,8-Tetracholorodibenzo-p-dioxins (TCDD) in rats

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dc.authoridTANYILDIZI, SADETTIN/0000-0001-7012-5392
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.contributor.authorCiftci, Osman
dc.contributor.authorTanyildizi, Sadettin
dc.contributor.authorGodekmerdan, Ahmet
dc.date.accessioned2024-08-04T20:35:43Z
dc.date.available2024-08-04T20:35:43Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a persistent environmental pollutant, on the percentage of T-cell subsets and B-lymphocyte and effectiveness of curcumin, beta-myrcene (myrcene) and 1,8-cineole (cineol) on this toxicity in rats. Rats (n = 112) were divided randomly into 8 equal groups. One group was kept as control and given corn oil as carrier. TCDD was orally administered at the dose of 2 mu g/kg/week. Curcumin, myrcene and cineol were orally administered by gavages at the doses of 100, 200 and 100 mg/kg/day, respectively, dissolved in corn oil with and without TCDD. The blood samples were taken from half of the rats on day 30 and from the rest on day 60 for the determination of lymphocyte subsets (CD3(+), CD4(+), CD8(+), CD161(+), CD45RA, CD4(+)CD25(+) and total lymphocyte). The results indicated that although TCDD significantly (p < 0.05) decreased the percentage of CD3(+), CD4(+), CD161(+), CD45RA, CD4(+)CD25(+) and total lymphocyte, it caused a significant increase in the percentage of CD8(+) cells. In contrast, curcumin, myrcene and cineol significantly decreased CD8(+) cells levels but increased CD3(+), CD4(+), CD161(+), CD45RA, CD4(+)CD25(+) and total lymphocyte cells populations. The beneficial effects of curcumin, myrcene and cineol and the toxic effects of TCDD were increased at day 60 compared to day 30. In conclusion, curcumin, myrcene and cineol showed immunomodulatory effects and eliminated TCDD-induced immune suppressive effects in rats.en_US
dc.description.sponsorshipTUBITAK (Scientific and Technical Research Council of the Turkish Republic) [106O815]en_US
dc.description.sponsorshipWe acknowledge the support of TUBITAK (Scientific and Technical Research Council of the Turkish Republic) under grant 106O815.en_US
dc.identifier.doi10.1177/0960327111404909
dc.identifier.endpage1994en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue12en_US
dc.identifier.pmid21450899en_US
dc.identifier.scopus2-s2.0-84856263145en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1986en_US
dc.identifier.urihttps://doi.org/10.1177/0960327111404909
dc.identifier.urihttps://hdl.handle.net/11616/95552
dc.identifier.volume30en_US
dc.identifier.wosWOS:000296893000013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject2, 3, 7, 8-TCDDen_US
dc.subjectcurcuminen_US
dc.subjectmyrceneen_US
dc.subjectcineolen_US
dc.subjectT-cell subsetsen_US
dc.subjectB cellsen_US
dc.titleCurcumin, myrecen and cineol modulate the percentage of lymphocyte subsets altered by 2,3,7,8-Tetracholorodibenzo-p-dioxins (TCDD) in ratsen_US
dc.typeArticleen_US

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