Investigation of protective effect of ellagic acid in phthalates-induced reproductive damage

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dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridaydin, muhterem/0000-0002-6494-9229
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidbasak, nese/ABH-5495-2020
dc.contributor.authorTurkmen, Nese Basak
dc.contributor.authorAyhan, Idris
dc.contributor.authorTaslidere, Asli
dc.contributor.authorAydin, Muhterem
dc.contributor.authorCiftci, Osman
dc.date.accessioned2024-08-04T20:49:07Z
dc.date.available2024-08-04T20:49:07Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPhthalates that people are exposed to every day are toxic carcinogenic chemicals with proven harmful effects on growth and reproduction. Ellagic acid (EA) is a polyphenol derivative known for its antioxidant properties. We hypothesized that the possible reproductive damage mechanism of phthalates is oxidative attack and ellagic acid could have a protective effect against radical forms in the body through its antioxidant properties. Thirty-two male rats were randomly divided into 4 groups, with 8 rats in each. Phthalate (DBP) was administered intraperitoneally and EA acid through gastric oral gavage (phthalate group 500 mg/kg/day DBP; EA group 2 mg/kg/day ellagic acid; the treatment group 500 mg/kg/day DBP and 2 mg/kg/day EA). The vehicle of DBP and EA, carboxymethyl cellulose was administered to control group. At the end of 4 weeks the testis tissue samples were taken under mild anesthesia. Tissue malondialdehyde, antioxidant parameters, sperm motility, sperm density and abnormal spermatozoon ratios were determined. Analysis was performed with One Way ANOVA test using SPSS 12.0 program. As a result; it has been shown that DBP causes oxidative damage by increasing the malondialdehyde level and decreasing antioxidant parameters, increased abnormal sperm rate and decreased sperm motility and concentration and histopathological damage so this damage is inhibited by the antioxidant activity of ellagic acid.en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumuen_US
dc.description.sponsorshipThe present research was financially supported by Turkiye Bilimsel ve Teknolojik Arastirma Kurumu.en_US
dc.identifier.doi10.1080/01480545.2020.1853764
dc.identifier.endpage1659en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue4en_US
dc.identifier.pmid33292028en_US
dc.identifier.scopus2-s2.0-85097385708en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1652en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2020.1853764
dc.identifier.urihttps://hdl.handle.net/11616/99663
dc.identifier.volume45en_US
dc.identifier.wosWOS:000597688700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEllagic aciden_US
dc.subjectantioxidanten_US
dc.subjectphthalateen_US
dc.subjectDBPen_US
dc.subjectreproductive damageen_US
dc.titleInvestigation of protective effect of ellagic acid in phthalates-induced reproductive damageen_US
dc.typeArticleen_US

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