Investigating the possible protective effect of caffeic acid phenethyl ester on aquaporin-2 changes in renal ischemia-reperfusion injury in rats

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dc.contributor.authorSapmaz, Hilal I.
dc.contributor.authorKose, Evren
dc.contributor.authorKaraca, Zeynal M.
dc.contributor.authorAkyurek, Sema
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorDeresoy, Faik A.
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2026-04-04T13:31:23Z
dc.date.available2026-04-04T13:31:23Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjective: We aimed to investigate the changes in renal aquaporins (AQP) of rats in renal ischemia-reperfusion (I/R) injury and the protective effects of caffeic acid phenethyl ester (CAPE) against these changes. Methods: Forty-five adult rats were divided into six groups: control, sham (right nephrectomy), I/R (right nephrectomy + left kidney I/R), I/R+CAPE (I/R procedure after i.p. CAPE), sham + CAPE, and sham + dimethyl sulfoxide. Blood urea nitrogen, Cr, and K+ levels were measured in the sera. Tissues were stained with hematoxylin and eosin for histopathological examination. For immunohistochemical analysis, AQP2 was applied using the streptavidin/biotin/peroxidase system. AQP2 gene expression in kidney tissues was examined by polymerase chain reaction (PCR). Results: In the I/R, congestion, inflammation, and necrosis were found to increase compared to the control. In the I/R+CAPE, improvement was observed in necrosis compared to the I/R. There was a decrease in AQP2 expression in the I/R. In PCR, no significant difference was observed in AQP2 gene expression between the I/R and control and between the I/R+CAPE and I/R. Conclusion: Renal I/R inhibits the production of AQP2 in the kidney and causes histological and biochemical damage. CAPE administration before I/R has a protective effect on the kidney.
dc.identifier.doi10.24875/CIRU.24000295
dc.identifier.endpage350
dc.identifier.issn0009-7411
dc.identifier.issue4
dc.identifier.orcid0000-0001-9497-3468
dc.identifier.pmid40825327
dc.identifier.scopus2-s2.0-105013688101
dc.identifier.scopusqualityQ3
dc.identifier.startpage341
dc.identifier.urihttps://doi.org/10.24875/CIRU.24000295
dc.identifier.urihttps://hdl.handle.net/11616/108773
dc.identifier.volume93
dc.identifier.wosWOS:001552749100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMexican Acad Surgery
dc.relation.ispartofCirugia Y Cirujanos
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectKidney
dc.subjectCaffeic acid
dc.subjectAntioxidant
dc.subjectRenal ischemia
dc.subjectPhytochemical
dc.subjectAquaporin-2
dc.titleInvestigating the possible protective effect of caffeic acid phenethyl ester on aquaporin-2 changes in renal ischemia-reperfusion injury in rats
dc.typeArticle

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