Investigation of the Effect of Local and Systemic Preoperative Dexamethasone Application on Bone Tissue Healing in Mandibular Bone Defects

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dc.authorscopusid57205661501
dc.authorscopusid55347265500
dc.authorscopusid14524170200
dc.authorscopusid57890322500
dc.contributor.authorYavuz G.Y.
dc.contributor.authorKeskinruzgar A.
dc.contributor.authorBozdag Z.
dc.contributor.authorBayazit S.
dc.date.accessioned2024-08-04T20:00:45Z
dc.date.available2024-08-04T20:00:45Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to investigate the effect of locally and systemically delivered single-dose corticosteroid injections on bone tissue. Study Design: A total of 84 Wistar albino rats were divided into 2 groups as local and systemic injection groups, and 2 groups as control and experiment among themselves. Before the procedure, dexamethasone was given to the experimental group and physiological saline was given to the control group. A defect was created in the jawbone. It was sacrificed on the third, seventh, and 40th days. The mandible bones of the sacrificed rats were removed and the healing of the bone tissue was examined histopathologically. Results: No significant difference was observed in the tissue sections of the subjects sacrificed after 40 days. However, the increase in fibroblastic connective tissue and the number of osteoblasts were less in the experimental local groups that were sacrificed after 7 days compared with the control groups (P=0.040 and 0.041). Again, it was determined that there was a statistically significant decrease in the experimental local group compared with the experimental systemic group (P=0.040 and 0.004). Conclusions: It can be said that single-dose corticosteroid applications cause a delay in bone healing in the early period. © 2024 by Mutaz B. Habal, MD.en_US
dc.description.sponsorshipAdiyaman Üniversitesi; 2020-0001en_US
dc.description.sponsorshipThis study was supported by Adiyaman University Scientific Research Projects (ADY\u00DC-BAP) Project Management Office with project number 2020-0001.en_US
dc.identifier.doi10.1097/SCS.0000000000010412
dc.identifier.issn1049-2275
dc.identifier.scopus2-s2.0-85198616947en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000010412
dc.identifier.urihttps://hdl.handle.net/11616/90952
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofJournal of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone healingen_US
dc.subjectcorticosteroiden_US
dc.subjectintramuscularen_US
dc.subjectsubmucosalen_US
dc.titleInvestigation of the Effect of Local and Systemic Preoperative Dexamethasone Application on Bone Tissue Healing in Mandibular Bone Defectsen_US
dc.typeArticleen_US

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