Effects of topical phenytoin on nasal wound healing after mechanical trauma An experimental study

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dc.contributor.authorŞimşek, Gökçe
dc.contributor.authorÇiftçi, Osman
dc.contributor.authorKaradağ, Neşe
dc.contributor.authorKarataş, Erkan
dc.contributor.authorKızılay, Ahmet
dc.date.accessioned2017-05-29T13:51:47Z
dc.date.available2017-05-29T13:51:47Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives/Hypothesis: Impaired postoperative wound healing is the second most common morbidity after synechia formation in endoscopic sinus surgery. The aim of this experimental study was to investigate the potential effects of topical phenytoin on wound healing after nasal mucosal trauma in rats. Study Design: An experimental study at the Inonu University Faculty of Medicine. Methods: Twenty-four rats were randomized into three groups: 1) phenytoin group (n 5 8), 2) control group (n 5 8), and 3) vehicle group (n 5 8). After damaging the right nasal cavity, in the phenytoin group, 1% topical phenytoin cream was applied for 7 days. The rats in the control group did not receive any treatment. The vehicle group was treated with daily topical cold cream for 1 week. The rats were sacrificed at the end, and the nasal cavities were excised. Tissue edema and inflammatory cell infiltration were compared among the groups. Additionally, proliferating cell nuclear antigen (PCNA) and cluster of differentiation 31 (CD31) immunoexpression levels were evaluated. Furthermore, in biochemical analysis, the tissue levels of vascular endothelial growth factor and (EGF) of the groups were investigated. Results: In the phenytoin group, tissue edema and inflammatory cell infiltration were significantly decreased, and PCNA and CD31 immunoexpression levels were more prominent (P <.001) and the tissue EGF levels were significantly higher (P <.01). Conclusions: Topical phenytoin treatment may alter the nasal wound healing after mechanical trauma. The potential beneficial effects of topical phenytoin on nasal mucosa should be investigated by further experimental and human trials.en_US
dc.identifier.citationŞimşek, G. Çiftçi, O. Karadağ, N. Karataş, E. Kızılay, A. (2014). Effects of topical phenytoin on nasal wound healing after mechanical trauma An experimental study. The Laryngoscope, 124(12), 449–454.en_US
dc.identifier.doi10.1002/lary.24811en_US
dc.identifier.endpage454en_US
dc.identifier.issn0023852X
dc.identifier.issue12en_US
dc.identifier.startpage449en_US
dc.identifier.urihttp://doi.wiley.com/10.1002/lary.24811
dc.identifier.urihttps://hdl.handle.net/11616/6992
dc.identifier.volume124en_US
dc.language.isoenen_US
dc.publisherThe Laryngoscopeen_US
dc.relation.ispartofThe Laryngoscopeen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNasal mucosaen_US
dc.subjectWound healingen_US
dc.subjectPhenytoinen_US
dc.subjectİntranasal administrationen_US
dc.subjectEpidermal growth factoren_US
dc.subjectVascular endothelial growth factoren_US
dc.subjectProliferating cell nuclear antigenen_US
dc.subjectCluster of differentiation 31en_US
dc.subjectRatsen_US
dc.subjectAnimal experimentationen_US
dc.titleEffects of topical phenytoin on nasal wound healing after mechanical trauma An experimental studyen_US
dc.typeArticleen_US

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