Gingko biloba Extract Inhibits Oxidative Stress and Ameliorates Impaired Glial Fibrillary Acidic Protein Expression, but Can Not Improve Spatial Learning in Offspring from Hyperhomocysteinemic Rat Dams

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dc.authoridKoz, Sema T/0000-0002-6342-0200
dc.authoridNedzvetsky, Nedzvetsky V., Nedzvetsky V.S., Nedzvetskii V.S., Nedzvetskiy V., Nedzvetskiy V., Viktor/0000-0001-7352-441X
dc.authoridBaydas, Giyasettin/0000-0002-9206-3177
dc.authorwosidKoz, Sema T/AAS-3664-2021
dc.authorwosidNedvetsky, Victor/V-3132-2017
dc.authorwosidBAYDAS, GIYASETTIN/AAI-4266-2021
dc.contributor.authorKoz, Sema T.
dc.contributor.authorBaydas, Giyasettin
dc.contributor.authorKoz, Suleyman
dc.contributor.authorDemir, Nevgul
dc.contributor.authorNedzvetsky, Viktor S.
dc.date.accessioned2024-08-04T20:36:00Z
dc.date.available2024-08-04T20:36:00Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe aimed to study the effects of gingko biloba extract (EGb) on oxidative stress, astrocyte maturation and cognitive disfunction in offspring of hyperhomocysteinemic rats. Hyperhomocysteinemia was induced in the pregnant rats by administration of methionine (1?gr/kg body weight) dissolved in drinking water throughout pregnancy. One group of animals has received same amount of methionine plus 100?mg/kg/day EGb during pregnancy. On the postnatal day 1, half of the pups from all groups were sacrificed to study the lipid peroxidation (LPO) in different subfractions of brain. Other half of pups were tested in Morris water maze to assess differences in learning and memory performance at the 75?days of age. Maternal hyperhomocysteinemia significantly increased LPO levels especially in mitochondrial subfraction of fetal pup brains. EGb significantly prevented this LPO inrease. Methionine administration to animals reduced glial fibrillary acidic protein (GFAP) expression in pup brains significantly. EGb administration improved GFAP expression significantly. Offspring of hyperhomocysteinemic animals had poor long term spatial memory performance on Morris water maze and EGb administration had no effect on impaired spatial memory. In conclusion, maternally induced hyperhomocysteinemia significantly increased oxidative stress, decreased expression of GFAP and impaired learning performance. Copyright (c) 2011 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/ptr.3669
dc.identifier.endpage955en_US
dc.identifier.issn0951-418X
dc.identifier.issn1099-1573
dc.identifier.issue7en_US
dc.identifier.pmid22076950en_US
dc.identifier.scopus2-s2.0-84863728716en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage949en_US
dc.identifier.urihttps://doi.org/10.1002/ptr.3669
dc.identifier.urihttps://hdl.handle.net/11616/95717
dc.identifier.volume26en_US
dc.identifier.wosWOS:000306085700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPhytotherapy Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGingko biloba extracten_US
dc.subjectprenatal hyperhomocysteinemiaen_US
dc.subjectoxidative stressen_US
dc.subjectcognitive functionen_US
dc.subjectpup brainen_US
dc.titleGingko biloba Extract Inhibits Oxidative Stress and Ameliorates Impaired Glial Fibrillary Acidic Protein Expression, but Can Not Improve Spatial Learning in Offspring from Hyperhomocysteinemic Rat Damsen_US
dc.typeArticleen_US

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