The effects of indomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandin E(2) and leukotriene C-4 levels after mesenteric ischemia-reperfusion injury

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dc.contributor.authorSare, M
dc.contributor.authorBozkurt, S
dc.contributor.authorOnuk, E
dc.contributor.authorOguz, M
dc.contributor.authorGurel, M
dc.contributor.authorErcan, S
dc.date.accessioned2024-08-04T20:11:51Z
dc.date.available2024-08-04T20:11:51Z
dc.date.issued1996
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, the changes of arachidonic acid metabolites after an ischemia-reperfusion (I/R) period are investigated. The cyclooxygenase and lipoxygenase metabolites were found to be significantly increased after a 45 min period of ischemia followed by 5 min of reperfusion. Prostaglandin E(2) (PGE(2))- and leukotriene C-4 (LTC(4))-like activities did not change in the ischemic period, but they both increased after reperfusion. A cyclooxygenase inhibitor indomethacin and lipoxygenase inhibitor nordehydroguaretic acid (NDGA) decreased PGE(2)- and LTC(4)-like activities, respectively, while allopurinol and superoxide dismutase (SOD) decreased both activities. According to our results, it can be assumed that free oxygen radicals are responsible for the elevation of PGE(2)- and LTC(4)-like activities and both of these arachidonic acid metabolites and free oxygen radicals are the main necrotizing agents in ischemia-reperfusion induced damage.en_US
dc.identifier.doi10.1016/S0952-3278(96)90120-9
dc.identifier.endpage383en_US
dc.identifier.issn0952-3278
dc.identifier.issue6en_US
dc.identifier.pmid9014215en_US
dc.identifier.scopus2-s2.0-0030458297en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage379en_US
dc.identifier.urihttps://doi.org/10.1016/S0952-3278(96)90120-9
dc.identifier.urihttps://hdl.handle.net/11616/93046
dc.identifier.volume55en_US
dc.identifier.wosWOS:A1996WA45800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofProstaglandins Leukotrienes and Essential Fatty Acidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntestinal Ischemiaen_US
dc.subjectFree-Radicalsen_US
dc.subjectIloprost Zk-36374en_US
dc.subjectRat-Liveren_US
dc.subjectPhospholipase-A2en_US
dc.subjectBiosynthesisen_US
dc.subjectMetabolismen_US
dc.subjectVerapamilen_US
dc.subjectNecrosisen_US
dc.subjectOxidaseen_US
dc.titleThe effects of indomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandin E(2) and leukotriene C-4 levels after mesenteric ischemia-reperfusion injuryen_US
dc.typeArticleen_US

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