Liver Transplantation for Hepatic Trauma: A Study From the European Liver Transplant Registry

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridDetry, Olivier/0000-0002-9436-6673
dc.authoridColledan, Michele/0000-0002-3880-4763
dc.authoridBechstein, Wolf/0000-0002-3267-8145
dc.authoridGr?t, Micha?/0000-0003-3372-3072
dc.authoridPolak, Wojciech/0000-0002-3096-4893
dc.authoridGómez-Bravo, Miguel A./0000-0002-5155-3508
dc.authorwosidMarin, Luis M M/C-6370-2015
dc.authorwosidBanares, Rafael/J-1460-2012
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidMajno-Hurst, Pietro/GYA-1260-2022
dc.authorwosidPinna, Antonio/AAC-6685-2019
dc.authorwosidDetry, Olivier/I-9333-2019
dc.authorwosidColledan, Michele/JGM-6908-2023
dc.contributor.authorKrawczyk, Marek
dc.contributor.authorGrat, Michal
dc.contributor.authorAdam, Rene
dc.contributor.authorPolak, Wojciech G.
dc.contributor.authorKlempnauer, Jurgen
dc.contributor.authorPinna, Antonio
dc.contributor.authorDi Benedetto, Fabrizio
dc.date.accessioned2024-08-04T20:42:45Z
dc.date.available2024-08-04T20:42:45Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. Liver transplantation is the most extreme form of surgical management of patients with hepatic trauma, with very limited literature data supporting its use. The aim of this study was to assess the results of liver transplantation for hepatic trauma. Methods. This retrospective analysis based on European Liver Transplant Registry comprised data of 73 recipients of liver transplantation for hepatic trauma performed in 37 centers in the period between 1987 and 2013. Mortality and graft loss rates at 90 days were set as primary and secondary outcome measures, respectively. Results. Mortality and graft loss rates at 90 days were 42.5% and 46.6%, respectively. Regarding general variables, cross-clamping without extracorporeal veno-venous bypass was the only independent risk factor for both mortality (P = 0.031) and graft loss (P = 0.034). Regarding more detailed factors, grade of liver trauma exceeding IV increased the risk ofmortality (P = 0.005) and graft loss (P = 0.018). Moreover, a tendency above the level of significance was observed for the negative impact of injury severity score (ISS) onmortality (P = 0.071). The optimal cutoff for ISS was 33, with sensitivity of 60.0%, specificity of 80.0%, positive predictive value of 75.0%, and negative predictive value of 66.7%. Conclusions. Liver transplantation seems to be justified in selected patients with otherwise fatal severe liver injuries, particularly in whom cross-clamping without extracorporeal bypass can be omitted. The ISS cutoff less than 33 may be useful in the selection process.en_US
dc.identifier.doi10.1097/TP.0000000000001398
dc.identifier.endpage2381en_US
dc.identifier.issn0041-1337
dc.identifier.issn1534-6080
dc.identifier.issue11en_US
dc.identifier.pmid27780185en_US
dc.identifier.scopus2-s2.0-84994520896en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2372en_US
dc.identifier.urihttps://doi.org/10.1097/TP.0000000000001398
dc.identifier.urihttps://hdl.handle.net/11616/97569
dc.identifier.volume100en_US
dc.identifier.wosWOS:000387370000024en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofTransplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject2-Stage Total Hepatectomyen_US
dc.subjectSuccessful Nonoperative Managementen_US
dc.subjectVenovenous Bypassen_US
dc.subjectHepatocellular-Carcinomaen_US
dc.subjectSurvival Benefiten_US
dc.subjectMultiple Traumaen_US
dc.subjectUnited-Statesen_US
dc.subjectInjuriesen_US
dc.subjectExperienceen_US
dc.subjectMortalityen_US
dc.titleLiver Transplantation for Hepatic Trauma: A Study From the European Liver Transplant Registryen_US
dc.typeArticleen_US

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