Remission of Diabetes Mellitus in Two Patients with Maturity-Onset Diabetes of the Young After Bariatric Surgery

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dc.authorwosidŞahin, İbrahim/HHY-8303-2022
dc.contributor.authorTopaloglu, Omercan
dc.contributor.authorEvren, Bahri
dc.contributor.authorSahin, Ibrahim
dc.date.accessioned2024-08-04T20:50:25Z
dc.date.available2024-08-04T20:50:25Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe present two cases with Maturity-onset diabetes of the young (MODY) undergoing bariatric surgery. Case 1: a 19-year-old woman using intensive insulin for type 1 diabetes mellitus (DM) was diagnosed with obesity. Body mass index (BMI) was 39.17 kg/m(2), fasting blood glucose (FBG) was 199 mg/dL, postprandial blood glucose (PPBG) was 239 mg/dL, glycated hemoglobin (HbA1c) was 11.1%, C-peptide (Cp) was 1.53 ng/mL, and antiGAD and ICA (islet cell autoantibody) were negative. Genetic analysis revealed a heterozygous mutation in HNF1A (MODY 3). We performed Roux-n-Y gastric bypass (RYGB). She discontinued insulin. Case 2: A 33-year-old woman using intensive insulin because of type 2 DM was diagnosed with obesity. BMI was 44.4 kg/m(2), FBG was 195 mg/dL, PPBG was 269 mg/dL, HbA1c was 9.4%, Cp was 1.89 ng/mL, and ICA and AntiGAD were negative. Genetic analysis revealed heterozygous mutation in KCNJ11 (MODY 13). RYGB was performed with an indication of morbid obesity. She discontinued insulin. RYGB was performed first in our cases for MODY. Improvement in glycemic regulation was higher than expected. A decision on bariatric surgery in patients with MODY should be made on the basis of the degree of obesity and glycemic status.en_US
dc.identifier.doi10.25179/tjem.2021-82457
dc.identifier.endpage254en_US
dc.identifier.issn1301-2193
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85110843926en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage249en_US
dc.identifier.urihttps://doi.org/10.25179/tjem.2021-82457
dc.identifier.urihttps://hdl.handle.net/11616/100056
dc.identifier.volume25en_US
dc.identifier.wosWOS:000663367200016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkish Journal of Endocrinology and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMaturity-onset diabetes of the young type 3en_US
dc.subjectbariatric surgeryen_US
dc.subjectgastric bypassen_US
dc.subjectdiabetes mellitusen_US
dc.titleRemission of Diabetes Mellitus in Two Patients with Maturity-Onset Diabetes of the Young After Bariatric Surgeryen_US
dc.typeArticleen_US

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