Investigation of Possible Effects of Exendin-4 during Exposure to Mild Chronic Stress on Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome in Rats

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridYildiz, Azibe/0000-0001-5686-7867;
dc.authorwosidYILDIZ, SEDAT/AAB-6354-2021
dc.authorwosidKOKSAL, Burcu/AAM-5664-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidKöksal, Burcu/JFK-5373-2023
dc.contributor.authorKoksal, Burcu
dc.contributor.authorYildiz, Sedat
dc.contributor.authorOzgocer, Tugba
dc.contributor.authorYildiz, Azibe
dc.contributor.authorVardi, Nigar
dc.contributor.authorBarutcu, Ozlem
dc.date.accessioned2024-08-04T20:49:05Z
dc.date.available2024-08-04T20:49:05Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of the study was to investigate the effects of Exendin-4 on polycystic ovary syndrome (PCOS) in rats in chronic mild stress medium. For establishing the PCOS model, dehydroepiandrosterone (DHEA) (6mg/100g) in 0.2ml sesame oil was injected subcutaneously to 21-day old rats (n = 67). In addition, 0.2ml sesame oil was injected subcutaneously to the rats in groups involving solution injection only. At the initial stage of the study, the rats were grouped as control, solution and PCOS, whereas stress and Exendin-4 groups were also added in the second stage of the study. In PCOS groups, Exendin-4 was applied intraperitoneally (10 mu g/kg/day) in mild chronic stress medium for four weeks. The results revealed that weight, fasting blood glucose, fasting blood insulin and HOMA-IR levels in the rats with PCOS were significantly higher than in the other groups; also, corticosterone levels of stress groups were significantly higher than in the other groups. In addition, harmful effects of PCOS on ovarian tissues were observed in histological examinations. However, after Exendin-4 application in PCOS groups, weight, fasting blood glucose, fasting blood insulin, HOMA-IR and LH/FSH levels were decreased, whereas Exendin-4 application in PCOS group treated with stress was not as effective as the application of Exendin-4 on rats with PCOS. Exendin-4 application also increased the number of healthy follicles in PCOS group, whereas there was no change in the number of healthy follicles in PCOS+Stress group.en_US
dc.identifier.doi10.5937/afmnai2001034K
dc.identifier.endpage47en_US
dc.identifier.issn0351-6083
dc.identifier.issn2217-2521
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85096315943en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage34en_US
dc.identifier.urihttps://doi.org/10.5937/afmnai2001034K
dc.identifier.urihttps://hdl.handle.net/11616/99634
dc.identifier.volume37en_US
dc.identifier.wosWOS:000568681500003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Nis, Fac Medicineen_US
dc.relation.ispartofActa Facultatis Medicae Naissensisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDHEAen_US
dc.subjectPCOSen_US
dc.subjectinsulin resistanceen_US
dc.subjectchronic stressen_US
dc.subjectSprague Dawleyen_US
dc.subjectExenatideen_US
dc.titleInvestigation of Possible Effects of Exendin-4 during Exposure to Mild Chronic Stress on Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome in Ratsen_US
dc.typeArticleen_US

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