The impact of transfusion burden and comorbidities on the prognosis of patients with myelodysplastic syndromes

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dc.authoridAr, Muhlis Cem/0000-0002-0332-9253
dc.authoridSARICI, Ahmet/0000-0002-5916-0119
dc.authoridAyer, Mesut/0000-0003-1977-0104
dc.authorwosidAr, Muhlis Cem/S-7530-2016
dc.authorwosidAltindal, Sermin/GQA-5282-2022
dc.authorwosidSARICI, Ahmet/ABI-7512-2020
dc.authorwosidAyer, Mesut/U-5707-2018
dc.contributor.authorSarici, Ahmet
dc.contributor.authorAr, Muhlis Cem
dc.contributor.authorYokus, Osman
dc.contributor.authorOngoren, Seniz
dc.contributor.authorAyer, Mesut
dc.contributor.authorAltindal, Sermin
dc.contributor.authorKoker, Hilal Tan
dc.date.accessioned2024-08-04T20:47:25Z
dc.date.available2024-08-04T20:47:25Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Early comorbidity detection has been reported to be associated with treatment-related outcomes in several diseases. Two main goals of the present study were to investigate both the impact of comorbidities and transfusion frequencies on the survival and quality of life of patients with myelodysplastic syndromes (MDS). Methods: One hundred and four MDS patients with a median International Prognostic Scoring System (IPSS) score of 0.5 (range: 0-3) were included in the study. Almost half of the patients had more than one comorbidity. Results: Median short form health surveys (SF)-36 mental and physical scores were 42.1 (range: 20.6-66.1) and 38.7 (range: 18-59.7), respectively. Mean scores of the Eastern Cooperative Oncology Group (ECOG) performance scales at diagnosis and during recruitment were 1.0 (1.4 +/- 1.0) and 2.0 (1.8 +/- 1.1), respectively. The mean Charlson Comorbidity Index (CCI) score was 1.0 (1.4 +/- 1.5). In the model that was constructed using variables with a p value < 0.100 in the univariate analysis, factors that predicted death were refractory anemia with excess blasts (RAEB) and ECOG scores at recruitment. When ECOG was removed from the model, RAEB and CCI at diagnosis moved to the forefront as mortality predictors. Conclusion: This study demonstrated that both CCI and ECOG performance status had an impact on survival in MDS patients who had low IPSS scores. ECOG stood out as a better and more practical predictor of survival than CCI, especially after considering its (ECOG) ease of use.en_US
dc.identifier.doi10.1016/j.transci.2020.102845
dc.identifier.issn1473-0502
dc.identifier.issue5en_US
dc.identifier.pmid32591291en_US
dc.identifier.scopus2-s2.0-85086878947en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2020.102845
dc.identifier.urihttps://hdl.handle.net/11616/99365
dc.identifier.volume59en_US
dc.identifier.wosWOS:000594185700028en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCharlson comorbidity indexen_US
dc.subjectECOGen_US
dc.subjectMyelodysplastic syndromeen_US
dc.subjectPrognosisen_US
dc.subjectSF-36en_US
dc.titleThe impact of transfusion burden and comorbidities on the prognosis of patients with myelodysplastic syndromesen_US
dc.typeArticleen_US

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