Antiapoptotic and antioxidant effects of ?-carotene against methotrexate-induced testicular injury

Basit Öğe Kaydı
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorVardi, Nigar
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorAtes, Burhan
dc.contributor.authorCetin, Asli
dc.contributor.authorOtlu, Ali
dc.date.accessioned2024-08-04T20:32:13Z
dc.date.available2024-08-04T20:32:13Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description9th National Congress of Histology and Embryology -- MAY 20-23, 2008 -- Adana, TURKEYen_US
dc.description.abstractObjective: To investigate the effect of beta-carotene against testicular injury induced by methotrexate (MTX). Design: Experimental study. Setting: Animal and histology laboratory at Inonu University. Animal(s): Twenty-eight Wistar male rats. Intervention(s): Twenty-eight rats were separated into four groups: control, beta-carotene, MTX, and beta-carotene + MTX. At the end of the treatment, the animals were killed, and tissue samples were examined via histologic and biochemical methods. Main Outcome Measure(s): in each group, 100 tubules were classified as intact, sloughing, atrophic, and degenerated. Caspase-3, a universal effector of apoptosis, was evaluated according to staining in place of coloring as weak, mild, and strong. Result(s): In the MTX group, 58.5 + 3.7% of tubules were sloughing, 10.8 + 2.1% of tubules were atrophic, and 2.0 + 0.6% of tubules were degenerative. In the beta-carotene + MTX group, the affected tubule number was statistically significantly lower than in the MTX group. The distribution of caspase-3 in the MTX group showed a statistically significant increase, but it decreased in the beta-carotene + MTX group. The enzyme activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GP-x) and the level of malondialdehyde (MDA) increased and decreased in parallel. Conclusion(s): Our results indicate that beta-carotene may be useful in decreasing the side effects of chemotherapy, including apoptotic cell death. (Fertil Steril(R) 2009;92:2028-33. (C)2009 by American Society for Reproductive Medicine.)en_US
dc.identifier.doi10.1016/j.fertnstert.2008.09.015
dc.identifier.endpage2033en_US
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue6en_US
dc.identifier.pmid19046577en_US
dc.identifier.scopus2-s2.0-70749083504en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2028en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2008.09.015
dc.identifier.urihttps://hdl.handle.net/11616/94917
dc.identifier.volume92en_US
dc.identifier.wosWOS:000272752600032en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility and Sterilityen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjecttesticular injuryen_US
dc.subjectcaspase-3en_US
dc.subjectbeta-caroteneen_US
dc.subjectoxidative damageen_US
dc.subjectmethotrexateen_US
dc.titleAntiapoptotic and antioxidant effects of ?-carotene against methotrexate-induced testicular injuryen_US
dc.typeConference Objecten_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu