Effects of esmolol, lidocaine and fentanyl on P wave dispersion, QT, QTc intervals and hemodynamic responses to endotracheal intubation during propofol induction: A comparative study

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dc.authorscopusid35240222100
dc.authorscopusid25645487000
dc.authorscopusid8948229000
dc.authorscopusid36198824500
dc.authorscopusid35317395700
dc.authorscopusid22956895300
dc.authorscopusid55204789700
dc.contributor.authorHanci V.
dc.contributor.authorYurtlu S.
dc.contributor.authorKaraba? T.
dc.contributor.authorOkyay D.
dc.contributor.authorHakimo?lu S.
dc.contributor.authorKayhan G.
dc.contributor.authorBüyükuysal T.
dc.date.accessioned2024-08-04T19:59:13Z
dc.date.available2024-08-04T19:59:13Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and objectives: In our study we aimed to investigate the effect of esmolol, lidocaine and fentanyl on P-wave dispersion (Pwd), QT and corrected QT (QTc) durations and hemodynamic responses to endotracheal intubation during propofol induction. Methods: A total of eighty adult patients, American Society of Anesthesiologists (ASA) Physical Status I or II aged 18 to 60 years were included in this prospective, randomised, double-blind study. All patients had control electrocardiograms (ECGs) done before anesthesia induction. The patients were randomised into four equal groups. The control group (Group C) received saline 5mL, the esmolol group (Group E) received esmolol 0.5mg.kg-1, the fentanyl group (Group F) received fentanyl 2?g.kg-1 and the lidocaine group (Group L) received lidocaine 1.5mg.kg-1 before anesthesia induction. Anesthesia was induced with intravenous propofol. ECGs for all patients were performed during the 1st and 3rd minutes of induction, 3minutes after administration of muscle relaxant, and at 5minutes and 10minutes after intubation. Pwd and QT intervals were measured on all ECGs. QTc intervals were determined using the Bazett formula. Heart rate (HR) and mean arterial pressure (MAP) were recorded before and after induction of anesthesia, immediately after intubation, and 1, 3, 5, 7 and 10minutes after intubation. Results: Compared with control, HR significantly increased in Group C, Group L and Group F after intubation. However, in Group E, there was no significant difference in HR values between control and after intubation. Compared with control, MAP significantly increased in Group C and Group L after the intubation. However, in Group E and Group F, there was no significant difference in MAP values between control and after the intubation. Compared with control, Pwd significantly increased in Group C after intubation. In Group L, Group F and Group E, there was no significant difference in Pwd values between control and after the intubation. Compared with control, QTc duration significantly increased in Group C and L after the intubation. In Group F and Group E, there was no significant difference in QTc durations between control and after the intubation. Conclusion: We concluded that administration of esmolol before intubation prevents tachycardia and an increase in MAP, Pwd and QTc duration caused by laryngoscopy and tracheal intubation. © 2013 Elsevier Editora Ltda..en_US
dc.identifier.doi10.1016/S0034-7094(13)70223-X
dc.identifier.endpage244en_US
dc.identifier.issn0034-7094
dc.identifier.issue3en_US
dc.identifier.pmid23683444en_US
dc.identifier.scopus2-s2.0-84877963864en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage235en_US
dc.identifier.urihttps://doi.org/10.1016/S0034-7094(13)70223-X
dc.identifier.urihttps://hdl.handle.net/11616/90463
dc.identifier.volume63en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofRevista Brasileira de Anestesiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnesthesiaen_US
dc.subjectElectrocardiographyen_US
dc.subjectFentanylen_US
dc.subjectIntubation, Intratrachealen_US
dc.subjectLidocaineen_US
dc.subjectPropanolamines/ esmololen_US
dc.subjectPropofolen_US
dc.titleEffects of esmolol, lidocaine and fentanyl on P wave dispersion, QT, QTc intervals and hemodynamic responses to endotracheal intubation during propofol induction: A comparative studyen_US
dc.typeArticleen_US

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