Effect of long-term therapy with sodium valproate on nail and serum trace element status in epileptic children

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dc.authoridArmutcu, Ferah/0000-0002-3218-9480
dc.authoridYakıncı, Mehmet Cengiz/0000-0001-5930-4269;
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.authorwosidArmutcu, Ferah/A-1364-2019
dc.authorwosidYakıncı, Mehmet Cengiz/ABI-7519-2020
dc.authorwosidVural, Hüseyin/B-3300-2016
dc.contributor.authorArmutcu, F
dc.contributor.authorOzerol, E
dc.contributor.authorGurel, A
dc.contributor.authorKanter, M
dc.contributor.authorVural, H
dc.contributor.authorYakinci, C
dc.contributor.authorAkyol, O
dc.date.accessioned2024-08-04T20:13:41Z
dc.date.available2024-08-04T20:13:41Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAntiepileptic drugs could cause changes in the trace element status of the body. Valproic acid (VPA) is a very effective anticonvulsant agent widely used in the management of various forms of epilepsy. Nail trace element content is a reliable index of trace element nutritional status of the body. To determine whether some of the side effects of antiepileptic drugs could be the result of zinc (Zn) depletion within tissues, Zn concentrations as well as copper (Cu) concentrations in nail and serum in 59 children having various types of epilepsy receiving valproate and 31 controls were assessed. Although serum Zn level in epileptic patients was found to be decreased, there was no difference in nail samples when compared to controls. There was a statistically significant increase in nail Cu level in epileptic patients when compared to controls. On the other hand, serum Cu levels were not different between the groups. Although none of our patients showed any symptoms of Cu elevation and Zn depletion, we should pay attention to potential body trace element changes in patients with epilepsy under VPA treatment. In conclusion, our results indicate that serum trace metal homeostasis might be affected by VPA therapy, but not by the convulsive disorder itself.en_US
dc.identifier.doi10.1385/BTER:102:1-3:001
dc.identifier.endpage10en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1-3en_US
dc.identifier.pmid15621922en_US
dc.identifier.scopus2-s2.0-12144283384en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1385/BTER:102:1-3:001
dc.identifier.urihttps://hdl.handle.net/11616/93784
dc.identifier.volume102en_US
dc.identifier.wosWOS:000226085500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsodium valproateen_US
dc.subjectserumen_US
dc.subjectnailen_US
dc.subjectzincen_US
dc.subjectcopperen_US
dc.titleEffect of long-term therapy with sodium valproate on nail and serum trace element status in epileptic childrenen_US
dc.typeArticleen_US

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