Laparoscopic Ovarian Drilling Improves Endometrial Homeobox Gene Expression in PCOS

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dc.authoridDalkilic, Semih/0000-0002-6892-247X
dc.authoridOTLU, BARIS/0000-0002-6220-0521;
dc.authorwosidŞentürk, Şenol/GPT-0116-2022
dc.authorwosidDalkilic, Semih/V-8138-2018
dc.authorwosidDalkılıç, Semih/GLV-3548-2022
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidUnlu, Cihat Mehmet/Q-5146-2018
dc.contributor.authorSenturk, Senol
dc.contributor.authorCelik, Onder
dc.contributor.authorDalkilic, Semih
dc.contributor.authorHatirnaz, Safak
dc.contributor.authorCelik, Nilufer
dc.contributor.authorUnlu, Cihat
dc.contributor.authorOtlu, Baris
dc.date.accessioned2024-08-04T20:47:09Z
dc.date.available2024-08-04T20:47:09Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe study was designed to investigate whether laparoscopic ovarian drilling (LOD) of ovaries alters the expression levels of HOXA-10 and HOXA-11 mRNA in the endometrium of infertile women with clomiphene-resistant PCOS. Expression of HOXA-10 and HOXA-11 mRNA in the endometrium obtained before and after LOD during the midsecretory phase was measured. Expression of each gene was evaluated using real-time reverse transcriptase polymerase chain reaction (RT-PCR). Expression levels of HOXA-10 and HOXA-11 mRNA were lower in endometrium of patients with PCOS before LOD compared with fertile controls. But the differences failed to show statistical significance. Compared with fertile subjects, LOD of PCOS ovaries up-regulated endometrial HOXA-10 and HOXA-11 mRNA expression. Fold changes of HOXA-10 and HOXA-11 mRNA after LOD were found to be 4.46 and 4.19, respectively. Fold change increase in HOXA-10 and HOXA-11 mRNA was found to be statistically significant (P < .01, P < .02). There is a receptivity defect in the endometrium of women with PCOS that affects fertility regardless of other causes of infertility. LOD increases endometrial HOXA-10 and HOXA-11 mRNA expressions and improves receptivity in patients with clomiphene-resistant PCOS.en_US
dc.identifier.doi10.1007/s43032-019-00072-x
dc.identifier.endpage680en_US
dc.identifier.issn1933-7191
dc.identifier.issn1933-7205
dc.identifier.issue2en_US
dc.identifier.pmid32046414en_US
dc.identifier.scopus2-s2.0-85079813935en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage675en_US
dc.identifier.urihttps://doi.org/10.1007/s43032-019-00072-x
dc.identifier.urihttps://hdl.handle.net/11616/99195
dc.identifier.volume27en_US
dc.identifier.wosWOS:000525433100026en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofReproductive Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPCOSen_US
dc.subjectOvarian drillingen_US
dc.subjectHOXA geneen_US
dc.subjectReceptivityen_US
dc.titleLaparoscopic Ovarian Drilling Improves Endometrial Homeobox Gene Expression in PCOSen_US
dc.typeArticleen_US

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