Chronic liver fibrosis induction in aging causes significant ultra-structural deterioration in liver and alteration on immune response gene expressions in liver-spleen axis

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dc.authoridKAYHAN, BASAK/0000-0003-3508-2563
dc.authoridKARACA, Zeynal Mete/0000-0002-5967-8102
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authorwosidKAYHAN, BASAK/ABH-9314-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.contributor.authorKaraca, Zeynal Mete
dc.contributor.authorKaraca, Gamze
dc.contributor.authorKayhan, Basak
dc.contributor.authorGul, Mehmet
dc.contributor.authorErsan, Veysel
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorYesilada, Elif
dc.date.accessioned2024-08-04T20:56:05Z
dc.date.available2024-08-04T20:56:05Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe relationship between damage to the liver and spleen by aging and the immune response status in these two organs, which are anatomically and immunologically interconnected, is unknown. The authors investigated the histopathological, ultrastructural, and immunological effects of aging in young and aged fibrotic mice by using an experimental model. Four groups were planned, with 10 mice in each experimental group. The levels of fibrosis and ultrastructural destruction in the liver were determined by alpha-SMA staining and TEM analysis. Expression levels of immunity genes (Il2, Il4, Il6, Il10, Il12, Il17, Tnf, Ifng, Tgfb1, Gata3, Rorc, Tbx21, Foxp3, Ccl2, Ccr2, Cxcr3, Pf4, Cxcl10) were carried out by qRT-PCR. While structural disorders were detected in the mitochondria of aged healthy group, cellular destruction in the fibrosis-induced elderly group was at a dramatic level. Fibrosis induction in aged mice caused an elevation in the expression of chemokines (CCl2, CXCL10, CCR2) and cytokine (IL-17a) genes that induce autoinflammatory response in the liver. Unlike the cellular pathology and genes activated in fibrosis in youth and the natural occurrence of fibrosis with aging, induction of fibrosis during aging causes deterioration in the liver and expression of genes responsible for autoimmunity in both the liver and spleen.en_US
dc.description.sponsorshipInonu Universitesi [TYL-2018- 1430]; Turkiye Bilimsel ve Teknolojik Arastimath;rma Kurumu (TUBITAK) [217S290]en_US
dc.description.sponsorshipThe work was supported by the Inonu Universitesi [TYL-2018- 1430]; Turkiye Bilimsel ve Teknolojik Arast & imath;rma Kurumu (TUBITAK) [217S290].en_US
dc.identifier.doi10.1080/01913123.2024.2360447
dc.identifier.endpage273en_US
dc.identifier.issn0191-3123
dc.identifier.issn1521-0758
dc.identifier.issue4en_US
dc.identifier.pmid38842161en_US
dc.identifier.scopus2-s2.0-85195314045en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage261en_US
dc.identifier.urihttps://doi.org/10.1080/01913123.2024.2360447
dc.identifier.urihttps://hdl.handle.net/11616/102041
dc.identifier.volume48en_US
dc.identifier.wosWOS:001253504500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofUltrastructural Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgingen_US
dc.subjectgene expressionen_US
dc.subjectimmune responseen_US
dc.subjectliver fibrosisen_US
dc.subjectspleenen_US
dc.titleChronic liver fibrosis induction in aging causes significant ultra-structural deterioration in liver and alteration on immune response gene expressions in liver-spleen axisen_US
dc.typeArticleen_US

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