Curcumin's effects on sialic acid level and sialidase activity in Ehrlich ascites tumor bearing mice

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dc.authoridAydın, Seval/0000-0001-6873-5730
dc.authoridOzen, Metehan/0000-0003-4088-3103
dc.authorwosidaydın, seval/AAD-3579-2021
dc.authorwosidAydın, Seval/D-5026-2019
dc.authorwosidOzen, Metehan/X-2705-2018
dc.authorwosidOzen, Metehan/E-2610-2016
dc.contributor.authorOzen, N
dc.contributor.authorUslu, E
dc.contributor.authorOzen, M
dc.contributor.authorAydin, S
dc.contributor.authorAltug, T
dc.contributor.authorBelce, A
dc.contributor.authorKokoglu, E
dc.date.accessioned2024-08-04T20:14:44Z
dc.date.available2024-08-04T20:14:44Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we determined curcumin's anticancer and chemopreventive effects in mice bearing Ehrlich ascites tumor by evaluation of cancer biomarkers, sialic acid level and sialidase activity. Both plasma sialic acid level and sialidase activity increased significantly in the mice group with Ehrlich ascites tumor. When the tumor groups fed with curcumin and fed with sesame oil were compared, sialic acid level and sialidase activity in ascites fluid significantly reduced in the group fed with curcumin in addition to the increases of plasma sialic acid level and sialidase activity. The tumor group fed with curcumin lived twice longer than the one fed with sesame oil. Curcumin as a phenolic compound decreased all these parameters in Ehrlich ascites tumors and lengthened survival by 88% in the mice with tumor. We concluded that curcumin has anticancer activity.en_US
dc.identifier.doi10.1620/tjem.197.221
dc.identifier.endpage227en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue4en_US
dc.identifier.pmid12434997en_US
dc.identifier.scopus2-s2.0-18744393374en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage221en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.197.221
dc.identifier.urihttps://hdl.handle.net/11616/93939
dc.identifier.volume197en_US
dc.identifier.wosWOS:000179052700004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcurcuminen_US
dc.subjectsialic aciden_US
dc.subjectsialidaseen_US
dc.subjectEhrlich ascites tumoren_US
dc.titleCurcumin's effects on sialic acid level and sialidase activity in Ehrlich ascites tumor bearing miceen_US
dc.typeArticleen_US

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