Determination of maternal serum pro-inflammatory cytokine changes in intrauterine growth restriction

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dc.authoridTanriverdi, Elif Seren/0000-0002-0449-0356
dc.authorwosidTanriverdi, Elif Seren/ABE-4472-2021
dc.contributor.authorKirici, P.
dc.contributor.authorCagiran, F. T.
dc.contributor.authorKali, Z.
dc.contributor.authorTanriverdi, E. F.
dc.contributor.authorMavral, N.
dc.contributor.authorEcin, S. M.
dc.date.accessioned2024-08-04T20:53:32Z
dc.date.available2024-08-04T20:53:32Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: To evaluate ma-ternal serum inflammatory marker changes in intrauterine growth restriction (IUGR) preg-nancies.PATIENTS AND METHODS: 50 healthy preg-nant women and 50 patients diagnosed with IU-GR were enrolled. Maternal serum high sensi-tivity C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), tumor necrosis fac-tor-alpha (TNF-alpha), interleukin (IL)-6, and IL-10 levels were measured before delivery and neonatal outcomes were evaluated.RESULTS: Birth weight, Apgar scores, and cord blood gas pH were lower in the IUGR group (p<0.001, p<0.001, p<0.001 and p=0.006, respectively). While the levels of ESR, hsCRP, IL-6, and TNF-alpha were higher, the IL-10 level was found to be lower in the IUGR group (p<0.001, p=0.033, p<0.001, p=0.004 and p<0.001, re-spectively). As ESR, hsCRP, and IL-6 levels in-creased, birth weight, Apgar scores, and cord blood gas pH decreased (p<0.001, p<0.001, p<0.001, p<0.001, p=0.02, p=0.002, p=0.001, p=0.03, p<0.001, p<0.001, p<0.001 and p=0.02, respectively). As TNF-alpha level increased, only birth weight and Apgar score at the 1st minute decreased (p=0.006 and p=0.048, respective-ly). As IL-10 level decreased, birth weight, Ap-gar scores, and cord blood gas pH decreased (p<0.001 for all). IL-6 (>3.2 pg/ml) had a sensi-tivity of 100%, specificity of 100%, PPV of 100% and NPV of 100%.CONCLUSIONS: While birth weight, Apgar score and cord blood pH decreased in IUGR cas-es, ESR, hsCRP, IL-6 and TNF-alpha levels increased. Combined measurement of these markers can be used for the diagnosis of IUGR.en_US
dc.identifier.endpage2001en_US
dc.identifier.issn1128-3602
dc.identifier.issue5en_US
dc.identifier.pmid36930498en_US
dc.identifier.scopus2-s2.0-85150666096en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1996en_US
dc.identifier.urihttps://hdl.handle.net/11616/101241
dc.identifier.volume27en_US
dc.identifier.wosWOS:000959553700034en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKey Intrauterine growth restrictionen_US
dc.subjectIL-6en_US
dc.subjectIL-10en_US
dc.subjectTNF-al-phaen_US
dc.titleDetermination of maternal serum pro-inflammatory cytokine changes in intrauterine growth restrictionen_US
dc.typeArticleen_US

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