Water Soluble Coumarin Quaternary Ammonium Chlorides: Synthesis and Biological Evaluation

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dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridGürses, Canbolat/0000-0002-4085-0224
dc.authoridKarataş, Mert Olgun/0000-0001-8500-2088
dc.authorwosidNOMA, SAMIR/ABH-1773-2021
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.authorwosidGürses, Canbolat/AAA-6825-2019
dc.authorwosidKarataş, Mert Olgun/ABG-7848-2020
dc.contributor.authorKaratas, Mert O.
dc.contributor.authorNoma, Samir A. A.
dc.contributor.authorGurses, Canbolat
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorAtes, Burhan
dc.contributor.authorAlici, Bulent
dc.contributor.authorCakir, Umit
dc.date.accessioned2024-08-04T20:48:53Z
dc.date.available2024-08-04T20:48:53Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the present study, coumarin-bearing three pyridinium and three tetra-alkyl ammonium salts were synthesized. The compounds were fully characterized by(1)H- and(13)C-NMR, LC/MS and IR spectroscopic methods and elemental analyses. The cytotoxic properties of all compounds were tested against human liver cancer (HepG2), human colorectal cancer (Caco-2) and non-cancer mouse fibroblast (L-929) cell lines. Some compounds performed comparable cytotoxicity with standard drug cisplatin. Antibacterial properties of the compounds were tested against Gram-negativeEscherichia coliand Gram-positiveBacillus subtilisbacteria, but the compounds did not have any antibacterial effect against both bacteria. Enzyme inhibitory properties of all compounds were tested on the activities of human carbonic anhydrase I and II, and xanthine oxidase. All compounds inhibited both enzymes more effectively than standard drugs, acetazolamide and allopurinol, respectively. The biological evaluation results showed that ionic and water soluble coumarin derivatives are promising structures for further investigations especially on enzyme inhibition field.en_US
dc.identifier.doi10.1002/cbdv.202000258
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue9en_US
dc.identifier.pmid32638471en_US
dc.identifier.scopus2-s2.0-85089958005en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202000258
dc.identifier.urihttps://hdl.handle.net/11616/99500
dc.identifier.volume17en_US
dc.identifier.wosWOS:000568032200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcoumarinen_US
dc.subjectcytotoxicityen_US
dc.subjectantimicrobial activityen_US
dc.subjectenzyme inhibitionen_US
dc.titleWater Soluble Coumarin Quaternary Ammonium Chlorides: Synthesis and Biological Evaluationen_US
dc.typeArticleen_US

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