Fruktozdan zengin beslenmede meteorin-like ve miyonektin düzeyleri üzerine egzersizin etkilerinin araştırılması
Küçük Resim Yok
Tarih
2024
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Yayıncı
İnönü Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Egzersizin metabolik hastalıklar üzerinde yararlı etkileri bildirilmesine rağmen, bu yararlı etkilerin mekanizmaları tam olarak anlaşılamamıştır. Egzersiz sırasında iskelet kasında salınan miyokinlerin yararlı etkileri olduğu gösterilmiştir. Çalışmamızda, fruktozdan zengin beslenen sıçanlarda meteorin-like ve miyonektin düzeylerinin böbrek fonksiyonları ile ilişkisi ve egzersizin meteorin-like ve miyonektin düzeylerine etkisinin araştırılması amaçlandı. Materyal ve metot: 24 adet 250-300 g ağırlığında Sprague-Dawley erkek sıçan eşit olarak, Kontrol, Fruktoz ve Fruktoz+Egzersiz gruplarına ayrıldı (n=24). Fruktoz ve Fruktoz+Egzersiz grup sıçanlara 8 hafta boyunca içme suyu içerisinde %20 oranında D-fruktoz çözeltisiyle beslendi. Fruktoz+Egzersiz grubundaki sıçanlar çalışmanın son 4 haftası 45 dk süreyle 20 m/dk hızda koşu bandında egzersiz yaptırıldı. Sıçanların 9.hafta ilk gün 24 saatlik idrarları toplandıktan sonra; anestezi altında kan, kas ve her iki böbreği alınarak ötenazi uygulandı. Bulgular: Çalışmamızda Kontrol grubuna göre Fruktoz grubunda kan basıncı değerlerinin yüksek olduğu belirlendi (p<0.01). Serum üre, glikoz, Lee indeksinin arttığı, serum K+, serum HDL ve serum P-3 konsantrasyonlarının azaldığı belirlendi (p<0.05). Fruktoz grubuna göre Fruktoz+Egzersiz grubunda serum miyonektin ve serum glikoz konsantrasyonlarının arttığı, serum üre, trigliserid, VLDL konsantrasyonlarının azaldığı belirlendi (p<0.05). Sonuç: Bu sonuçlar ışığında fruktozdan beslenmenin kan basıncını, glikoz ve trigliserid seviyelerini arttırıcı etkisi obeziteyi tanımlayabilecek düzey olarak değerlendirildi. Miyonektin düzeylerindeki artış egzersizin iyileştirici etkisi ile ilişkilendirilebileceği düşünüldü. Fruktozun metabolik etkilerinin egzersiz ile ilişkisinin, egzersizin uygulama süresi, egzersiz türü, başlama zamanı ve fruktoz ile besleme süresi, verilen doz ve veriliş yolu yeniden düzenlenerek daha kapsamlı araştırmaların yapılması gerektiğini düşünüyoruz. Anahtar Kelimeler: Egzersiz, fruktoz, metabolik sendrom, meteorin-like, miyonektin
Aim: Although beneficial effects of exercise on metabolic diseases have been reported, the mechanisms of these beneficial effects are not fully understood. Myokines released in skeletal muscle during exercise have been shown to have beneficial effects. Our study aimed to investigate the relationship between meteorin-like and myonectin levels and kidney functions in fructose-rich rats and the effect of exercise on meteorin-like and myonectin levels. Material and method: 24 Sprague-Dawley male rats weighing 250-300 g were equally divided into Control, Fructose and Fructose+Exercise groups (n = 24). Fructose and Fructose+Exercise group rats were fed with 20% D-fructose solution in drinking water for 8 weeks. Rats in the Fructose+Exercise group were exercised on a treadmill at a speed of 20 m/min for 45 minutes in the last 4 weeks of the study. After collecting the 24-hour urine of the rats on the first day of the 9th week; Euthanasia was performed under anesthesia by removing blood, muscle and both kidneys. Results: In our study, blood pressure values were determined to be higher in the Fructose group compared to the Control group (p<0.01). It was determined that serum urea, glucose, Lee index increased, serum K+, serum HDL and serum P-3 concentrations decreased (p<0.05). It was determined that serum myonectin and serum glucose concentrations increased and serum urea, triglyceride and VLDL concentrations decreased in the Fructose+Exercise group compared to the Fructose group (p<0.05). Conclusion: In the light of these results, the increasing effect of fructose nutrition on blood pressure, glucose and triglyceride levels was evaluated as a level that could define obesity. It was thought that the increase in myonectin levels could be associated with the healing effect of exercise. We think that more comprehensive research should be conducted on the relationship between the metabolic effects of fructose and exercise by rearranging the duration of exercise, type of exercise, starting time and duration of fructose feeding, dose given and route of administration. Key Words: Exercise, fructose, metabolic syndrome, meteorin-like, myonectin
Aim: Although beneficial effects of exercise on metabolic diseases have been reported, the mechanisms of these beneficial effects are not fully understood. Myokines released in skeletal muscle during exercise have been shown to have beneficial effects. Our study aimed to investigate the relationship between meteorin-like and myonectin levels and kidney functions in fructose-rich rats and the effect of exercise on meteorin-like and myonectin levels. Material and method: 24 Sprague-Dawley male rats weighing 250-300 g were equally divided into Control, Fructose and Fructose+Exercise groups (n = 24). Fructose and Fructose+Exercise group rats were fed with 20% D-fructose solution in drinking water for 8 weeks. Rats in the Fructose+Exercise group were exercised on a treadmill at a speed of 20 m/min for 45 minutes in the last 4 weeks of the study. After collecting the 24-hour urine of the rats on the first day of the 9th week; Euthanasia was performed under anesthesia by removing blood, muscle and both kidneys. Results: In our study, blood pressure values were determined to be higher in the Fructose group compared to the Control group (p<0.01). It was determined that serum urea, glucose, Lee index increased, serum K+, serum HDL and serum P-3 concentrations decreased (p<0.05). It was determined that serum myonectin and serum glucose concentrations increased and serum urea, triglyceride and VLDL concentrations decreased in the Fructose+Exercise group compared to the Fructose group (p<0.05). Conclusion: In the light of these results, the increasing effect of fructose nutrition on blood pressure, glucose and triglyceride levels was evaluated as a level that could define obesity. It was thought that the increase in myonectin levels could be associated with the healing effect of exercise. We think that more comprehensive research should be conducted on the relationship between the metabolic effects of fructose and exercise by rearranging the duration of exercise, type of exercise, starting time and duration of fructose feeding, dose given and route of administration. Key Words: Exercise, fructose, metabolic syndrome, meteorin-like, myonectin
Açıklama
Anahtar Kelimeler
Fizyoloji, Physiology
