Bispectral Index Monitoring to Guide End-Tidal Isoflurane Concentration at Three Phases of Operation in Patients With End-Stage Liver Disease Undergoing Orthotopic Liver Transplantation

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dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authoridGedik, Ender/0000-0002-7175-207X
dc.authoridToprak, Hüseyin İlksen/0000-0001-9293-8116
dc.authorwosidaydogan, mustafa said/AAA-2828-2021
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.authorwosidGedik, Ender/ABI-2971-2020
dc.authorwosidToprak, Hüseyin İlksen/AAN-4023-2020
dc.contributor.authorToprak, H. I.
dc.contributor.authorSener, A.
dc.contributor.authorGedik, E.
dc.contributor.authorUcar, M.
dc.contributor.authorKarahan, K.
dc.contributor.authorAydogan, M. S.
dc.contributor.authorErsoy, M. O.
dc.date.accessioned2024-08-04T20:32:49Z
dc.date.available2024-08-04T20:32:49Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description22nd Congress of the Spanish-Liver-Transplantation-Society (SETH) -- OCT 29-30, 2010 -- Madrid, SPAINen_US
dc.description.abstractIt has been shown that anesthetic requirements during liver transplantation are inversely proportional to the degree of hepatic dysfunction. We investigate alterations during the three phases of requirements for intraoperative isoflurane within the target of 40 to 55 Bispectral Index (BIS) values concerning patients with end-stage liver disease who are undergoing liver transplantation. After faculty ethics committee approval, we studied 50 patients of (age range, 18 to 65 years) who were undergoing liver transplantation. After induction, we used isoflurane with air/oxygen (FiO(2) = 0.5%) for anesthestic maintenance. The isoflurane concentration was set within the range of 40 to 55 BIS values. Remifentanil (0.15 mu g/kg/min) was infused for analgesia and cisatracurium was administered via continuous infusion. After anesthetic induction, we inserted arterial, pulmonary artery, and central venous catheters. The heart rate, mean arterial pressure (MAP), mean pulmonary arterial pressure (MPAP), body temperature, BIS values, end-tidal isoflurane concentration (ETiso) and end-tidal carbon dioxide concentration (ETCO(2)) were recorded at 30-minute intervals during the dissection and neohepatic phases, at 15-minute intervals during the anhepatic phase. In addition, we calculated the cardiac index during the three phases. There was no difference in heart rates among the operative phases. In contrast, there were significant changes in MAP, MPAP, BIS, ETCO(2) and body temperature values. However, all of these parameters were in physiological ranges and clinically acceptable. The ETiso values were lowest in the anhepatic phase compared to other phases, but the differences were not clinically important. The ETiso values in the dissection and neohepatic phases were compared with the anhepatic phase higher 5% and 8.6% respectively. During liver transplantation, ETiso requirement for the anhepatic phase was lower compared with the other two phases within the range of 40 to 55 BIS values.en_US
dc.description.sponsorshipSpanish Liver Transplantation Socen_US
dc.identifier.doi10.1016/j.transproceed.2010.11.023
dc.identifier.endpage895en_US
dc.identifier.issn0041-1345
dc.identifier.issue3en_US
dc.identifier.pmid21486622en_US
dc.identifier.scopus2-s2.0-79954497303en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage892en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2010.11.023
dc.identifier.urihttps://hdl.handle.net/11616/95299
dc.identifier.volume43en_US
dc.identifier.wosWOS:000289860300052en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlveolar Anesthetic Concentrationen_US
dc.subjectRecoveryen_US
dc.subjectPropofolen_US
dc.titleBispectral Index Monitoring to Guide End-Tidal Isoflurane Concentration at Three Phases of Operation in Patients With End-Stage Liver Disease Undergoing Orthotopic Liver Transplantationen_US
dc.typeConference Objecten_US

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