The beneficial effects of fish oil following cisplatin-induced oxidative and histological damage in liver of rats

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dc.authorscopusid27867577100
dc.authorscopusid57196485131
dc.authorscopusid57196486403
dc.contributor.authorCiftci O.
dc.contributor.authorOnatb E.
dc.contributor.authorCetinc A.
dc.date.accessioned2024-08-04T20:02:33Z
dc.date.available2024-08-04T20:02:33Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study investigated the protective effect of fish oil (FO) on cisplatin (CP) toxicity in the rat liver. Twenty-eight rats were divided equally into four groups, with the first being a control group. The second group (CP group) was given 7 mg/kg of CP and the third group (FO group) was given 1 FO softgel/rat/day for 14 days. The rats in the fourth group (CP + FO group) were treated with both CP and FO at the above doses. CP treatment caused significant oxidative damage via an increase in thiobarbituric acid reactive substances (TBARS) and reduced antioxidant defenses through a decrease in the activities of catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), and glutathione peroxidase (GPx) in rat liver tissue. Also, CP caused histopathological abnormalities, including necrosis, in the liver tissue. However, concurrent FO treatment prevented the negative oxidative and histopathological effects of CP. In conclusion, CP treatment can cause hepatotoxicity in rats, but dietary supplementation with FO can attenuate the oxidative and histological changes caused by CP. Thus, FO may be useful in preventing CP-induced hepatotoxicity in cancer patients. © 2017 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services.en_US
dc.identifier.endpage1431en_US
dc.identifier.issn1735-0328
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85033560545en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1424en_US
dc.identifier.urihttps://hdl.handle.net/11616/91783
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIranian Journal of Pharmaceutical Researchen_US
dc.relation.ispartofIranian Journal of Pharmaceutical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectFish oilen_US
dc.subjectHepatotoxicityen_US
dc.subjectHistological damageen_US
dc.subjectOxidative damageen_US
dc.titleThe beneficial effects of fish oil following cisplatin-induced oxidative and histological damage in liver of ratsen_US
dc.typeArticleen_US

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