Montelukast attenuates side effects of cisplatin including testicular, spermatological, and hormonal damage in male rats

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dc.authoridYILMAZ, Fethi/0000-0002-5041-9390
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridOguzturk, Hakan/0000-0002-9800-1428
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidYILMAZ, Fethi/W-9442-2018
dc.authorwosidoguzturk, hakan/Q-6242-2019
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidOguzturk, Hakan/AAC-3915-2021
dc.contributor.authorBeytur, Ali
dc.contributor.authorCiftci, Osman
dc.contributor.authorOguz, Fatih
dc.contributor.authorOguzturk, Hakan
dc.contributor.authorYilmaz, Fethi
dc.date.accessioned2024-08-04T20:35:44Z
dc.date.available2024-08-04T20:35:44Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the current study, the protective effect of montelukast (ML) on cisplatin induced reproductive toxicity in rats was investigated. Twenty-eight rats were equally divided into four groups; first group was kept as control. In the second group, ML was orally administered at the dose of 10 mg/kg/day for 10 days. In the third group, CP was intraperitoneally administered at the dose of 7 mg/kg a single injection, and in fourth group, CP and ML were given together at the same doses. Although CP induced oxidative stress via significant increase in the formation of TBARS, it caused a significant decline in the levels of GSH, CAT, GPx, and SOD in rats. In contrast, ML prevents these effects of CP through cause an increase in GSH, CAT, GPx, and SOD levels and a decrease in formation of TBARS. In addition, sperm motility and serum testosterone levels significantly decrease and histopathological damage increases with CP treatment. However, the effects of CP on sperm motility, serum testosterone level, oxidative and histopathological changes are eliminated by ML treatment. In conclusion, the current study demonstrated that the reproductive toxicity caused by CP may be prevented by ML treatment. Thus, it was judged that co-administration of ML with CP may be useful to attenuate the negative effects of CP on male reproductive system.en_US
dc.identifier.doi10.1007/s00280-011-1692-y
dc.identifier.endpage213en_US
dc.identifier.issn0344-5704
dc.identifier.issn1432-0843
dc.identifier.issue1en_US
dc.identifier.pmid21681572en_US
dc.identifier.scopus2-s2.0-84856757022en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://doi.org/10.1007/s00280-011-1692-y
dc.identifier.urihttps://hdl.handle.net/11616/95560
dc.identifier.volume69en_US
dc.identifier.wosWOS:000298652100023en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCancer Chemotherapy and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectMontelukasten_US
dc.subjectReproductive toxicityen_US
dc.subjectTestosteroneen_US
dc.subjectOxidative damageen_US
dc.subjectSperm qualityen_US
dc.titleMontelukast attenuates side effects of cisplatin including testicular, spermatological, and hormonal damage in male ratsen_US
dc.typeArticleen_US

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