Serum Gamma-Glutamyl Transferase (GGT) Levels and Inflammatory Activity in Patients With Non-dipper Hypertension

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dc.authoridCansel, Mehmet/0000-0003-4740-4371
dc.authoridAkaycan, Jülide/0000-0002-9174-6777
dc.authoridPekdemir, Hasan/0000-0002-4913-5120;
dc.authorwosidCansel, Mehmet/ABI-6324-2020
dc.authorwosidErmis, Necip/A-5184-2018
dc.authorwosidAkaycan, Jülide/ABI-2397-2020
dc.authorwosidPekdemir, Hasan/ABI-6096-2020
dc.authorwosidÇUĞLAN, bilal/AAP-8878-2021
dc.authorwosidErmis, Necip/HJP-7061-2023
dc.contributor.authorErmis, Necip
dc.contributor.authorYagmur, Julide
dc.contributor.authorAcikgoz, Nusret
dc.contributor.authorCansel, Mehmet
dc.contributor.authorCuglan, Bilal
dc.contributor.authorPekdemir, Hasan
dc.contributor.authorOzdemir, Ramazan
dc.date.accessioned2024-08-04T20:36:01Z
dc.date.available2024-08-04T20:36:01Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNon-dipper hypertension is associated with increased cardiovascular morbidity and mortality. We aimed to evaluate serum gamma-glutamyl transferase (GGT) level, which is accepted as a marker for oxidative stress and its relationship with inflammatory activity in patients with non-dipper hypertension. Age and sex matched 43 dipper hypertensive patients, 40 non-dipper patients, and 46 healthy subjects were included into the study. Serum GGT and C-reactive protein (CRP) levels were measured and compared between each of the groups. Serum GGT activity was higher in the non-dipper and the dipper hypertensive groups than in the control group (33.5 +/- 11.8 and 28.1 +/- 10.1 U/l, respectively, vs. 21.2 +/- 6.5U/l; p < 0.001). There was a statistically significant difference in serum GGT activity between the non-dippers and the dippers (p = 0.021). When compared with the control group, serum CRP levels were significantly increased in both the non-dipper and the dipper hypertensive groups (6.1 +/- 2.6 and 5.4 +/- 2.1 mg/l, respectively, vs. 2.8 +/- 1.7mg/L; p < 0.001). Increased CRP levels were higher in non-dippers than dippers (p = 0.046). A significant correlation was found between GGT and CRP measurements (r = 0.37, p = 0.002). Serum GGT levels, which are markers of the oxidative stress and CRP levels, are both increased in non-dipper hypertension. Increased GGT activity, found to be correlated with CRP levels, may be one of the reasons behind the non-dipper hypertension related cardiovascular complications.en_US
dc.identifier.doi10.3109/10641963.2011.577485
dc.identifier.endpage315en_US
dc.identifier.issn1064-1963
dc.identifier.issue5en_US
dc.identifier.pmid21797800en_US
dc.identifier.scopus2-s2.0-84863902301en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://doi.org/10.3109/10641963.2011.577485
dc.identifier.urihttps://hdl.handle.net/11616/95724
dc.identifier.volume34en_US
dc.identifier.wosWOS:000306476700002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofClinical and Experimental Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnon-dipper hypertensionen_US
dc.subjectGamma-glutamyl transferase and CRPen_US
dc.titleSerum Gamma-Glutamyl Transferase (GGT) Levels and Inflammatory Activity in Patients With Non-dipper Hypertensionen_US
dc.typeArticleen_US

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