The Protective Effects of Apocynin on Kidney Damage Caused by Renal Ischemia/Reperfusion

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidaltintas, ramazan/AAP-2348-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorAltintas, Ramazan
dc.contributor.authorPolat, Alaadin
dc.contributor.authorVardi, Nigar
dc.contributor.authorOguz, Fatih
dc.contributor.authorBeytur, Ali
dc.contributor.authorSagir, Mustafa
dc.contributor.authorYildiz, Azibe
dc.date.accessioned2024-08-04T20:37:52Z
dc.date.available2024-08-04T20:37:52Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: This experimental study was designed to explore the protective effect of apocynin, the NADPH-oxidase inhibitor, on kidney damage induced by ischemia/reperfusion (I/R) in a rat model. Methods: Thirty-two rats were randomly divided into a control group and three I/R groups (1-hour ischemia followed by 23-hour reperfusion). Three I/R groups were treated by apocynin (20 mg/kg, i.p.) at two different time points (before ischemia and during ischemia). The histopathological findings, including apoptotic changes, and also tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathion peroxidase (GPX), reduced glutathione (GSH), myeloperoxidase (MPO), blood urea nitrogen (BUN), and serum creatinine (Cr) levels, were determined. Results: Kidney tissue MDA and MPO, and serum BUN and Cr levels were found to be significantly higher in the I/R group, but there was no statistically significant difference in the levels of SOD, CAT, GPX, and GSH between the I/R and the control groups. Although apocynin significantly reduced MDA and MPO in group 3 and increased GPX in both treatment groups when compared to the I/R group, the elevated BUN and Cr levels were significantly reduced in treatment groups. Renal I/R injury also induced extensive tubular necrosis, glomerular damage, and apoptosis in the histological evaluation. Apocynin, especially when used during ischemia, ameliorated these histological damages in different amounts in treatment groups. Conclusion: The beneficial effects of apocynin on renal I/R injury were evaluated for the first time.en_US
dc.identifier.doi10.1089/end.2012.0556
dc.identifier.endpage624en_US
dc.identifier.issn0892-7790
dc.identifier.issn1557-900X
dc.identifier.issue5en_US
dc.identifier.pmid23387559en_US
dc.identifier.scopus2-s2.0-84885930710en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage617en_US
dc.identifier.urihttps://doi.org/10.1089/end.2012.0556
dc.identifier.urihttps://hdl.handle.net/11616/96240
dc.identifier.volume27en_US
dc.identifier.wosWOS:000318552100017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal of Endourologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectNadph Oxidase Activationen_US
dc.subjectPhenethyl Ester Capeen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectFree-Radicalsen_US
dc.subjectGlutathioneen_US
dc.subjectExpressionen_US
dc.subjectInhibitoren_US
dc.subjectOxidationen_US
dc.subjectPreventsen_US
dc.titleThe Protective Effects of Apocynin on Kidney Damage Caused by Renal Ischemia/Reperfusionen_US
dc.typeArticleen_US

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