Determination of risk factors affecting mortality in patients with gastrointestinal perforation after pediatric liver transplantation

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dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridKutluturk, Koray/0000-0002-7030-4953
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridÖzgör, Dinçer/0000-0001-8519-8869
dc.authoridBarut, Bora/0000-0001-9489-5973
dc.authoridKoc, Cemalettin/0000-0002-5676-6772
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidKutluturk, Koray/S-5493-2019
dc.authorwosidBarut, Bora/ABD-9882-2020
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidÖzgör, Dinçer/AAB-3523-2021
dc.authorwosidKoc, Cemalettin/B-6430-2018
dc.contributor.authorBarut, Bora
dc.contributor.authorAkbulut, Sami
dc.contributor.authorKutluturk, Koray
dc.contributor.authorKoc, Cemalettin
dc.contributor.authorOzgor, Dincer
dc.contributor.authorAydin, Cemalettin
dc.contributor.authorSelimoglu, Ayse
dc.date.accessioned2024-08-04T20:45:53Z
dc.date.available2024-08-04T20:45:53Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractGastrointestinal perforation (GIP) is one of the most serious complications occurring after liver transplantation (LT), especially in pediatric patients. This study aimed to determine the risk factors affecting mortality in pediatric patients with GIP after LT. GIP developed in 37 (10%) of 370 pediatric patients who underwent LT at our institute. Patients were divided into two groups: alive (n = 22) or dead (n = 15), and both groups were compared in terms of demographic and clinical parameters using univariate analysis. There was no statistically significant difference between groups in either demographic or clinical parameters, except for perforation site (P = 0.001) and median follow-up (P = 0.001). Stomas arose in 17 (45.9%) patients: 76% of patients with stomas and 45% of those without survived (P = 0.052). Kaplan-Meier analysis indicated that patients with stomas had a significantly higher overall survival (P = 0.029) and that patients with duodenal and colonic perforation had a significantly lower overall survival. Multivariate analysis showed that re-perforation was an independent risk factor for mortality (P = 0.035; OR: 17.674; 95% CI for OR: 1.233-253.32). Although there are many options for management of GIP, including primary repair, resection plus anastomosis, and resection plus end or loop ostomy, gastrointestinal diversion is still the best option.en_US
dc.identifier.doi10.1111/petr.13415
dc.identifier.issn1397-3142
dc.identifier.issn1399-3046
dc.identifier.issue4en_US
dc.identifier.pmid30973664en_US
dc.identifier.scopus2-s2.0-85064493479en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/petr.13415
dc.identifier.urihttps://hdl.handle.net/11616/98763
dc.identifier.volume23en_US
dc.identifier.wosWOS:000470844700013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgastrointestinal diversionen_US
dc.subjectGIPen_US
dc.subjectmortalityen_US
dc.subjectpediatric liver transplantationen_US
dc.subjectre-perforationen_US
dc.titleDetermination of risk factors affecting mortality in patients with gastrointestinal perforation after pediatric liver transplantationen_US
dc.typeArticleen_US

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