The effects of duration of CO2 insufflation and irrigation on peritoneal microcirculation assessed by free radical scavengers and total glutathion levels during operative laparoscopy

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dc.authoridBuhur, Ali/0000-0003-1228-0962
dc.authorwosidtaskin, omur/C-6864-2016
dc.authorwosidBuhur, Ali/GLQ-5966-2022
dc.contributor.authorTaskin, O
dc.contributor.authorBuhur, A
dc.contributor.authorBirincioglu, M
dc.contributor.authorBurak, F
dc.contributor.authorAtmaca, R
dc.contributor.authorYilmaz, I
dc.contributor.authorWheeler, JM
dc.date.accessioned2024-08-04T20:11:58Z
dc.date.available2024-08-04T20:11:58Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description26th Annual Meeting of the American-Association-of-Gynecologic-Laparoscopists -- SEP 23-29, 1997 -- SEATTLE, WASHINGTONen_US
dc.description.abstractStudy Objective. To investigate the effects of peritoneal exposure to carbon dioxide (CO2) on peritoneal microcirculation and free radical scavenger (FRS) metabolism, and its role in potential adhesion formation after operative laparoscopy. Design. Randomized, controlled study (Canadian Task Force classification I). Setting. University-affiliated hospital. Patients. Twenty-eight women undergoing operative laparoscopy for adnexal masses. Intervention. For each patient, a 1 x I-cm sidewall peritoneal flap was excised at the end of laparoscopy and numbered randomly. Similar flaps obtained from 24 women immediately after entering the abdomen during laparotomy served as controls. Measurements and Main Results. Changes in glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) levels were studied in homogenized peritoneal tissues. The duration of CO2 exposure and amount of CO2 used were correlated with levels of free radical scavengers and compared with controls. Mean CO2 exposure, amount of CO2 used, and CO2 pressure (15 mm Hg) was similar between low irrigation and irrigated laparoscopy (118.3 +/- 25 and 39.2 +/- 8.81 min and 125 +/- 20 and 44.5 +/- 6.81 min, respectively). The change in FRS levels was significantly correlated with duration and amount of CO2 exposure ( r = -0.92). Levels of GSH-Px, SOD, CAT, and GSH were significantly lower in the CO2 exposure group than in controls (0.57 els of GSH-Px, SOD, CAT; and GSH were significantly lower in the CO2 exposure group than in controls (0.57 mu mol, 1.8 ng, 48.5 mu mol, 1.5 nmol vs 0.8 mu mol, 2.6 +/- 0.4 ng, 79 mu mol, 3.6 nmol, respectively). Conclusion, Exposure to CO2 has adverse effects on peritoneal microcirculation and cell-protective systems, which are proposed mechanisms in adhesion formation. Avoiding long CO2 exposure and copiously irrigating the abdominal cavity throughout surgery may lessen these effects. The potential role of the peritoneal FRS system on postoperative adhesion formation and its relation to estrogen status mandates further studies.en_US
dc.description.sponsorshipAmer Assoc Gynecol Laparoscopistsen_US
dc.identifier.doi10.1016/S1074-3804(98)80078-9
dc.identifier.endpage133en_US
dc.identifier.issn1074-3804
dc.identifier.issue2en_US
dc.identifier.pmid9564059en_US
dc.identifier.scopus2-s2.0-0031594878en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage129en_US
dc.identifier.urihttps://doi.org/10.1016/S1074-3804(98)80078-9
dc.identifier.urihttps://hdl.handle.net/11616/93100
dc.identifier.volume5en_US
dc.identifier.wosWOS:000073847100007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJournal Amer Assoc Gynecologic Laparoscopistsen_US
dc.relation.ispartofJournal of The American Association of Gynecologic Laparoscopistsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPostoperative Adhesion Formationen_US
dc.subjectOxygen Free-Radicalsen_US
dc.subjectPeroxidase-Activityen_US
dc.subjectRandomized Trialen_US
dc.subjectLaparotomyen_US
dc.subjectSurgeryen_US
dc.subjectReperfusionen_US
dc.subjectModelen_US
dc.subjectRaten_US
dc.titleThe effects of duration of CO2 insufflation and irrigation on peritoneal microcirculation assessed by free radical scavengers and total glutathion levels during operative laparoscopyen_US
dc.typeConference Objecten_US

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