Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women

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dc.authorwosidÖzerol, İbrahim Halil/ABI-8015-2020
dc.authorwosidIldiz, Nilay Gucluer/AAJ-9263-2021
dc.contributor.authorBayraktar, Mehmet Refik
dc.contributor.authorOzerol, Ibrahim Halil
dc.contributor.authorGucluer, Nilay
dc.contributor.authorCelik, Onder
dc.date.accessioned2024-08-04T20:32:17Z
dc.date.available2024-08-04T20:32:17Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Mycoplasma hominis and Ureaplasma urealyticum are important opportunistic pathogens implicated in urogenital infections and complicated pregnancy. We aimed to study the role of these pathogens in symptomatic and asymptomatic pregnant women and determine their clinical significance and antibiotic susceptibility. Methods: One hundred pregnant women were included in the study, 50 symptomatic patients and 50 asymptomatic controls. Duplicate endocervical samples were taken from each individual and analyzed using the Mycoplasma IST-2 kit and A7 agar medium. Antimicrobial susceptibility was tested against doxycycline, josamycin, ofloxacin, erythromycin, tetracycline, ciprofloxacin, azithromycin, clarithromycin, and pristinamycin using the Mycoplasma IST-2 kit. Results: Twelve symptomatic pregnant women had spontaneous abortions. Of these, eight (66.7%) cases had been colonized with M. hominis and/or U. urealyticum. Of the pregnant women infected with M. hominis and/or U. urealyticum, 40.7% delivered a low birth weight infant. M. hominis was successfully cultured in five women (5%) and U. urealyticum in 27 (27%). Among positive cultures, 15.6% and 84.4% of isolates were M. hominis and U. urealyticum, respectively. M. hominis and U. urealyticum were uniformly susceptible to doxycycline, tetracycline, and pristinamycin, which may be successfully used in the empirical therapy of infected individuals. Conclusions: It can be concluded that genital colonization with M. hominis and U. urealyticum may predispose to spontaneous abortion and low birth weight. (C) 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipInonu Universityen_US
dc.description.sponsorshipWe gratefully acknowledge Inonu University for financial support. We also acknowledge the physicians of the Maternity Clinic of Turgut Ozal Medical Center for their help in enrolling pregnant women in this prospective study. This work was presented in part at the International Union of Microbiology Societies 12th International Congress of Bacteriology and Applied Microbiology, held in Istanbul on August 5-9, 2008. Conflict of interest: No conflict of interest to declare.en_US
dc.identifier.doi10.1016/j.ijid.2009.03.020
dc.identifier.endpageE95en_US
dc.identifier.issn1201-9712
dc.identifier.issn1878-3511
dc.identifier.issue2en_US
dc.identifier.pmid19515594en_US
dc.identifier.scopus2-s2.0-76449099079en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE90en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijid.2009.03.020
dc.identifier.urihttps://hdl.handle.net/11616/94975
dc.identifier.volume14en_US
dc.identifier.wosWOS:000275513100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofInternational Journal of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMycoplasma hominisen_US
dc.subjectUreaplasma urealyticumen_US
dc.subjectSpontaneous abortionen_US
dc.subjectLow birth weighten_US
dc.subjectAntibiotic susceptibilityen_US
dc.titlePrevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant womenen_US
dc.typeArticleen_US

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