A case-control study on effects of the ATM, RAD51 and TP73 genetic variants on colorectal cancer risk

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dc.authoridYilmaz, Umit/0000-0003-0248-3483
dc.authoridYilmaz, Nesibe/0000-0002-5527-8507
dc.authoridYazıcı, Merve/0000-0001-6598-2816
dc.authorwosidYilmaz, Umit/JFA-5784-2023
dc.authorwosidKeskin, Metin/AAY-8567-2020
dc.authorwosidZeybek, Sakir Umit/AAD-2960-2020
dc.authorwosidYilmaz, Nesibe/JFK-5834-2023
dc.authorwosidYazıcı, Merve/HKV-4923-2023
dc.contributor.authorYazici, Merve
dc.contributor.authorYilmaz, Umit
dc.contributor.authorYilmaz, Nesibe
dc.contributor.authorCelik, Faruk
dc.contributor.authorIsikoren, Ece Gizem
dc.contributor.authorCelikel, Burcu
dc.contributor.authorErgen, Arzu
dc.date.accessioned2024-08-04T20:47:03Z
dc.date.available2024-08-04T20:47:03Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: ATM, RAD51 and TP73 are genes that take part in DNA repair pathways. The aim of this prospective case-control study was to determine the genotype and allele distributions of the ATM 5'-UTR G/A, RAD51 135 G/C and TP73 GC/AT polymorphisms and their relationship with clinical parameters in Turkish colorectal cancer (CRC) patients. Material and methods: One hundred and four CRC patients and 113 healthy individuals were included in this study as control. The polymerase chain reaction-restriction fragment length polymorphism techniques were used. Results: The ATM 5'-UTR G/A polymorphism GG (p = 0.001) and AA (p = 0.0001) genotypes were found higher in the patient group, while the GA genotype (p = 0.0001) and A allele (p= 0.001) were significantly higher in the control group. Moreover, the GG genotype (p = 0.042) was higher among patients with advanced-stage cancer and, while GA genotype (p = 0.047) was increased in patients without perineural invasion. The RAD51 135 G/C polymorphism GC genotype (p= 0.0001) and C allele (p = 0.0001) were significantly higher in the patient group, while CC genotype (p= 0.0001) was higher in the control group. No statistical significance was observed between the TP73 GC/AT polymorphism genotype and allele distribution and the clinical parameters. Conclusion: In the Turkish population, the ATM 5'-UTR GG and AA genotypes, and the RAD51 135 G/C GC genotype and the C allele presence may be risk factors for CRC.en_US
dc.description.sponsorshipResearch Fund of Istanbul University [49683]en_US
dc.description.sponsorshipThe present work was supported by the Research Fund of Istanbul University (Project no: 49683).en_US
dc.identifier.doi10.1515/tjb-2019-0222
dc.identifier.endpage786en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85077569554en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage778en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2019-0222
dc.identifier.urihttps://hdl.handle.net/11616/99135
dc.identifier.volume44en_US
dc.identifier.wosWOS:000501564800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColorectal canceren_US
dc.subjectATMen_US
dc.subjectRAD51en_US
dc.subjectTP73en_US
dc.subjectPCR-RFLPen_US
dc.titleA case-control study on effects of the ATM, RAD51 and TP73 genetic variants on colorectal cancer risken_US
dc.typeArticleen_US

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