Preparation and evaluation of fast-dissolving albendazole sulfoxide and praziquantel-loaded polyvinylpyrrolidone nanofiber films by electrospinning

Basit Öğe Kaydı
dc.authoridFilazi, Ayhan/0000-0002-2800-6215
dc.authorwosidGültekin, Yakup/KCJ-7772-2024
dc.authorwosidFilazi, Ayhan/AAA-7163-2019
dc.contributor.authorGultekin, Yakup
dc.contributor.authorKorkmaz, Cagla
dc.contributor.authorOzturk, Naile
dc.contributor.authorFilazi, Ayhan
dc.contributor.authorDeniz, Ahmet
dc.contributor.authorDog, Osman
dc.contributor.authorPezik, Esra
dc.date.accessioned2024-08-04T20:54:58Z
dc.date.available2024-08-04T20:54:58Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAlbendazole sulfoxide (ALBSOX) and Praziquantel (PRZ) are broad-spectrum anthelmintic medications used in the treatment of both humans and animals that are challenging to manufacture for geriatric and pediatric populations and have poor oral bioavailability due to their low water solubility and high lipophilicity. To increase the solubility and bioavailability of the drugs, ALBSOX and PRZ-loaded nanofiber films were prepared using polyvinylpyrrolidone K90 (PVP), a non-toxic, inert polymer with high hydrophilic characteristics. SEM analysis of the produced ALBSOX and PRZ-loaded PVP nanofiber films revealed them to be uniform and smooth, with good uniformity and mechanical properties. The PVP nanofiber films of ALBSOX and PRZ disintegrated in phosphate buffer (pH 6.8) in less than 1 s and increased the solubility of ALBSOX and PRZ about five times compared to pure active ingredients. Furthermore, the prepared ALBSOX and PRZ-loaded PVP nanofiber films were found to have no cytotoxic effect in cell viability studies using L929 cells, and increased the protoscolicidal effect of the ALBSOX and PRZ combination approximately 2-fold in studies of Echinococcus granulosus protoscoleces. The findings of the present study reveal that the developed PVP nanofiber films have the potential to improve the dissolution profile and pharmacological efficacy of the ALBSOX and PRZ.en_US
dc.description.sponsorshipHacettepe University Scientific Research Projects Coordination Unit [TSA-2021-19166]en_US
dc.description.sponsorshipFunding This study was supported by the Hacettepe University Scientific Research Projects Coordination Unit [grant number TSA-2021-19166] .en_US
dc.identifier.doi10.1016/j.jddst.2023.105304
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85181495084en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2023.105304
dc.identifier.urihttps://hdl.handle.net/11616/101755
dc.identifier.volume92en_US
dc.identifier.wosWOS:001156220500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlbendazole sulfoxideen_US
dc.subjectEchinococcus granulosusen_US
dc.subjectNanofiberen_US
dc.subjectPolyvinylpyrrolidoneen_US
dc.subjectPraziquantelen_US
dc.titlePreparation and evaluation of fast-dissolving albendazole sulfoxide and praziquantel-loaded polyvinylpyrrolidone nanofiber films by electrospinningen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu