Magnetic resonance spectroscopy features of normal-appearing white matter in patients with acute brucellosis

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dc.authoridmemişoğlu, funda/0000-0003-3905-1182
dc.authoridKayabas, Uner/0000-0002-5323-0796
dc.authoridBayindir, Yasar/0000-0003-3930-774X
dc.authoridKarakas, Hakki/0000-0002-1328-8520
dc.authorwosidmemişoğlu, funda/AAA-4392-2021
dc.authorwosidKayabas, Uner/JRX-1616-2023
dc.authorwosidBayindir, Yasar/T-1523-2017
dc.contributor.authorKayabas, Uner
dc.contributor.authorAlkan, Alpay
dc.contributor.authorFirat, Ahmet Kemal
dc.contributor.authorKarakas, Hakki Muammer
dc.contributor.authorBayindir, Yasar
dc.contributor.authorYetkin, Funda
dc.date.accessioned2024-08-04T20:30:41Z
dc.date.available2024-08-04T20:30:41Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe aimed to evaluate whether the subtle metabolic cerebral changes are present in normal-appearing white matter on conventional MRI, in patients with acute brucellosis, by using MR spectroscopy (MRS). Sixteen patients with acute brucellosis and 13 healthy control subjects were investigated with conventional MRI and single-voxel MRS. Voxels were placed in normal-appearing parietal white matter (NAPWM). N-Acetyl aspartate (NAA)/creatine (Cr) and choline (Cho)/Cr ratios were calculated. There was no significant difference between the study subjects and the control group in NAA/Cr ratios obtained from NAPWM. However, the Cho/Cr ratios were significantly higher in patients with acute brucellosis compared to controls (p=0.01). MRS revealed metabolic changes in normal-appearing white matter of patients with brucellosis. Brucellosis may cause subtle cerebral alterations, which may only be discernible with MRS. Increased Cho/Cr ratio possibly represents an initial phase of inflammation and/or demyelination process of brucellosis. (C) 2007 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejrad.2007.08.034
dc.identifier.endpage420en_US
dc.identifier.issn0720-048X
dc.identifier.issn1872-7727
dc.identifier.issue3en_US
dc.identifier.pmid17920223en_US
dc.identifier.scopus2-s2.0-39649122878en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage417en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejrad.2007.08.034
dc.identifier.urihttps://hdl.handle.net/11616/94464
dc.identifier.volume65en_US
dc.identifier.wosWOS:000254595300011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofEuropean Journal of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbrucellosisen_US
dc.subjectmagnetic resonance spectroscopyen_US
dc.subjectbrainen_US
dc.titleMagnetic resonance spectroscopy features of normal-appearing white matter in patients with acute brucellosisen_US
dc.typeArticleen_US

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