Serum interleukin-2, interleukin-6, tumour necrosis factor-alpha and nitric oxide levels in patients with Behçet's disease

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dc.authorscopusid9839426100
dc.authorscopusid6701663429
dc.authorscopusid6602779940
dc.authorscopusid6602213979
dc.authorscopusid6603760794
dc.contributor.authorAkdeniz N.
dc.contributor.authorEsrefoglu M.
dc.contributor.authorKeleş M.S.
dc.contributor.authorKarakuzu A.
dc.contributor.authorAtasoy M.
dc.date.accessioned2024-08-04T19:59:22Z
dc.date.available2024-08-04T19:59:22Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Behçet's disease (BD) is a chronic systemic disorder characterised by oral and genital ulcerative lesions, ocular and cutaneous manifestations. Cytokines are the major mediators of immunologic and inflammatory reactions. Nitric oxide is reactive nitrogen intermediate which plays a key role in pathogenesis of many inflammatory and autoimmune skin diseases. The study was conducted to determine serum interleukin-2 (IL-2), interleukin-6 (IL-6), tumour necrosis factor (TNF)-alpha and nitric oxide levels in relation to the pathogenesis of Behçet's disease. Materials and Methods: Serum IL-2, IL-6, and TNF-alpha levels were measured with test kits by enzyme-linked immunosorbent assay (ELISA) method, while serum nitric oxide levels were determined with a test kit by colorimetric method. Serum IL-2, IL-6, TNF-alpha and nitric oxide concentrations in 27 patients with Behçet's disease and in 16 healthy controls were determined by extrapolation from their standard curves. The significance of the mean differences between the 2 groups was assessed by the Mann-Whitney U test. Results: The serum levels of IL-2, IL-6, TNF-alpha, and nitric oxide concentrations in patients with BD were significantly higher than those of the controls (P <0.001). Conclusion: Our results suggest that elevated levels of IL-2, IL-6, TNF-alpha, and nitric oxide in Behçet's disease appear to be related to the disease.en_US
dc.identifier.endpage599en_US
dc.identifier.issn0304-4602
dc.identifier.issue5en_US
dc.identifier.pmid15531955en_US
dc.identifier.scopus2-s2.0-10344258543en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage596en_US
dc.identifier.urihttps://hdl.handle.net/11616/90585
dc.identifier.volume33en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademy of Medicine Singaporeen_US
dc.relation.ispartofAnnals of the Academy of Medicine Singaporeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytokineen_US
dc.subjectSkin diseaseen_US
dc.subjectVasculitisen_US
dc.titleSerum interleukin-2, interleukin-6, tumour necrosis factor-alpha and nitric oxide levels in patients with Behçet's diseaseen_US
dc.typeArticleen_US

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