Protective effects of caffeic acid phenethyl ester on doxorubicin-induced cardiotoxicity in rats

Basit Öğe Kaydı
dc.authoridYAGMURCA, MURAT/0000-0001-9774-8151
dc.authoridIrmak, M. Kemal/0000-0002-1903-8303
dc.authoridAkpinar, Mehmet/0000-0002-4220-8390
dc.authorwosidOztas, Emin/B-5730-2016
dc.authorwosidYAĞMURCA, Murat/AAH-4496-2019
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidYAGMURCA, MURAT/A-1851-2018
dc.authorwosidErdogan, Hasan/AFN-9249-2022
dc.authorwosidIrmak, M. Kemal/H-6667-2014
dc.authorwosidAkpinar, Mehmet/GLS-3733-2022
dc.contributor.authorFadillioglu, E
dc.contributor.authorOztas, E
dc.contributor.authorErdogan, H
dc.contributor.authorYagmurca, M
dc.contributor.authorSogut, S
dc.contributor.authorUcar, M
dc.contributor.authorIrmak, MK
dc.date.accessioned2024-08-04T20:13:37Z
dc.date.available2024-08-04T20:13:37Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description28th National Congress of Physiology -- SEP 24-27, 2002 -- IZMIR, TURKEYen_US
dc.description.abstractThe prevention of doxorubicin (DXR)-induced cardiotoxicity may be helpful to improve future DXR therapy. The aim of this study was to investigate the cardio-protective effects of caffeic acid phenethyl ester (CAPE), an antioxidant agent, on DXR-induced cardiotoxicity. Rats were divided into three groups and treated with saline, DXR and DXR + CAPE. Rats were treated with CAPE (10 gmol kg(-1) day(-1) i.p.) or saline starting 2 days before a single dose of DXR (20 mg kg(-1) i.p.). Ten days later, haemodynamic measurements were performed and the hearts were excised for biochemical analyses and microscopic examination. The heart rate and mean blood pressure were higher and the pulse pressure was lower in the DXR group than in the other two groups. The administration of DXR alone resulted in higher myeloperoxidase activity, lipid peroxidation and protein carbonyl content than in the other groups. The activities of superoxide dismutase and catalase were higher in DXR and DXR + CAPE groups than in the saline group. Rats in the DXR + CAPE group had increased catalase activity in comparison with the DXR group and high glutathione peroxidase activity in comparison with the other two groups. There was severe disruption of mitochondrial fine structure in the electron microscopy of the DXR group. In contrast, myocardial microscopy appeared nearly normal in the DXR + CAPE group (as defined at the electron microscopic level). In light of these in vivo haemodynamic, enzymatic and morphological results, we conclude that CAPE pretreatment significantly attenuated DXR-induced cardiac injury, possibly with its antioxidant effects. Copyright (C) 2004 John Wiley Sons, Ltd.en_US
dc.identifier.doi10.1002/jat.945
dc.identifier.endpage52en_US
dc.identifier.issn0260-437X
dc.identifier.issn1099-1263
dc.identifier.issue1en_US
dc.identifier.pmid14745846en_US
dc.identifier.scopus2-s2.0-0842344493en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.1002/jat.945
dc.identifier.urihttps://hdl.handle.net/11616/93743
dc.identifier.volume24en_US
dc.identifier.wosWOS:000188501100007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Applied Toxicologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdoxorubicinen_US
dc.subjectCAPEen_US
dc.subjectcardiotoxicityen_US
dc.subjectantioxidantsen_US
dc.subjectlipid peroxidationen_US
dc.subjectultrastructureen_US
dc.titleProtective effects of caffeic acid phenethyl ester on doxorubicin-induced cardiotoxicity in ratsen_US
dc.typeConference Objecten_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu