Invasive meningococcal disease in adolescents and young adults

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dc.authorscopusid7402529732
dc.authorscopusid7006441998
dc.authorscopusid7005234691
dc.authorscopusid6603164027
dc.authorscopusid24344675200
dc.authorscopusid55065583600
dc.authorscopusid6602322733
dc.contributor.authorHarrison L.H.
dc.contributor.authorPass M.A.
dc.contributor.authorMendelsohn A.B.
dc.contributor.authorEgri M.
dc.contributor.authorRosenstein N.E.
dc.contributor.authorBustamante A.
dc.contributor.authorRazeq J.
dc.date.accessioned2024-08-04T19:59:14Z
dc.date.available2024-08-04T19:59:14Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractContext: Incidence of invasive meningococcal disease has increased recently in persons aged 15 through 24 years. Objective: To characterize meningococcal infection in adolescents and young adults in Maryland during the 1990s. Design and Setting: Population-based surveillance study for meningococcal disease from January 1, 1990, through December 31, 1999, in Maryland. Patients: Maryland residents diagnosed as having invasive meningococcal disease. Main Outcome Measure: Invasive meningococcal infection. Results: Of 295 total cases, 71 (24.1%) occurred among persons aged 15 through 24 years. Sixteen (22.5%) of these cases were fatal. The annual incidence rate increased from 0.9 to 2.1 cases per 100000 among 15 through 24 year olds (P=.01). The proportion of all disease increased from 16.0% to 28.9% (P=.03). The incidence and proportion of cases subsequently decreased to 1.0 and 16.4% in 1998 through 1999, respectively. Infection in 15 through 24 year olds was more likely to be fatal than infection in those younger than age 15 years (22.5% vs 4.6%; P=.001). Infection in 15 through 24 year olds, compared with those aged 25 years or older, was more likely to be associated with male sex (66.2% vs 34.8%; P<.001) and serogroup C infection (46.9% vs 20.2 %; P<.001), respectively. Infections were potentially preventable with the licensed meningococcal vaccine in 82.8% of 15 through 24 year olds, 68.1% of those younger than 15 years, and 76.8% of adults aged 25 years or older. Conclusions: Incidence of meningococcal infection in 15 through 24 year olds in Maryland increased and then declined during the 1990s. Infection in this age group was associated with an unusually high case-fatality ratio, and the vast majority of cases were potentially vaccine preventable.en_US
dc.identifier.doi10.1001/jama.286.6.694
dc.identifier.endpage699en_US
dc.identifier.issn0098-7484
dc.identifier.issue6en_US
dc.identifier.pmid11495619en_US
dc.identifier.scopus2-s2.0-0035827876en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage694en_US
dc.identifier.urihttps://doi.org/10.1001/jama.286.6.694
dc.identifier.urihttps://hdl.handle.net/11616/90495
dc.identifier.volume286en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmerican Medical Associationen_US
dc.relation.ispartofJAMAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadolescenten_US
dc.subjectadulten_US
dc.subjectageen_US
dc.subjectarticleen_US
dc.subjectdemographyen_US
dc.subjectfatalityen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectincidenceen_US
dc.subjectmaleen_US
dc.subjectmeningococcosisen_US
dc.subjectpriority journalen_US
dc.subjectsex ratioen_US
dc.subjectstatistical analysisen_US
dc.subjectUnited Statesen_US
dc.subjectvaccinationen_US
dc.titleInvasive meningococcal disease in adolescents and young adultsen_US
dc.typeArticleen_US

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