The effect of caffeic acid phenethyl ester on bacterial translocation and intestinal damage in cholestatic rats
Yükleniyor...
Dosyalar
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Digestive Diseases and Sciences
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Abstract We investigated the effect of caffeic acid
phenethyl ester in rat ileum injury induced by chronic biliary
obstruction. Swiss albino rats were divided into three groups:
Group 1, sham (n = 7); Group 2, common bile duct ligation
(n = 7); and Group 3, common bile duct ligation plus caffeic
acid phenethyl ester (n = 7). In the caffeic acid phenethyl
ester-treated rats, ileum tissue levels of malondialdehyde
and myeloperoxidase were significantly lower than those
of the bile duct-ligated rats (P < 0.001). The levels of tumor
necrosis factor-α, interleukin-6, and interleukin-1α in the
caffeic acid phenethyl ester group were significantly lower
than those in the bile duct ligation group (P < 0.03, P < 0.01,
and P < 0.02 respectively). The present study demonstratesthat intraperitoneal administration of caffeic acid phenethyl
ester in bile duct-ligated rats reduces intestinal oxidative
stress. This effect may be useful in the preservation of intestinal
damage in cholestasis.
Açıklama
Anahtar Kelimeler
Common bile duct ligation, Bacterial translocation, Caffeic acid phenethyl ester, Oxidative stress, Cytokines
Kaynak
Digestive Diseases and Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
51
Sayı
10
Künye
Ara, C. Eşrefoğlu, M. Polat, A. Işık, B. Aladağ, M. Gül, M. Ay, S. Tekerekoğlu, M. S. Yılmaz, S. (2006). The effect of caffeic acid phenethyl ester on bacterial translocation and intestinal damage in cholestatic rats. Digestive Diseases and Sciences, 51(10), 1754–1760.
