The effect of caffeic acid phenethyl ester on bacterial translocation and intestinal damage in cholestatic rats

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dc.authorid110105en_US
dc.contributor.authorAra, Cengiz
dc.contributor.authorEşrefoğlu, Mukaddes
dc.contributor.authorPolat, Alattin
dc.contributor.authorIşık, Burak
dc.contributor.authorAladağ, Murat
dc.contributor.authorGül, Mehmet
dc.contributor.authorAy, Selma
dc.contributor.authorTekerekoğlu, Mehmet Sait
dc.contributor.authorYılmaz, Sezai
dc.date.accessioned2017-08-10T06:08:35Z
dc.date.available2017-08-10T06:08:35Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAbstract We investigated the effect of caffeic acid phenethyl ester in rat ileum injury induced by chronic biliary obstruction. Swiss albino rats were divided into three groups: Group 1, sham (n = 7); Group 2, common bile duct ligation (n = 7); and Group 3, common bile duct ligation plus caffeic acid phenethyl ester (n = 7). In the caffeic acid phenethyl ester-treated rats, ileum tissue levels of malondialdehyde and myeloperoxidase were significantly lower than those of the bile duct-ligated rats (P < 0.001). The levels of tumor necrosis factor-α, interleukin-6, and interleukin-1α in the caffeic acid phenethyl ester group were significantly lower than those in the bile duct ligation group (P < 0.03, P < 0.01, and P < 0.02 respectively). The present study demonstratesthat intraperitoneal administration of caffeic acid phenethyl ester in bile duct-ligated rats reduces intestinal oxidative stress. This effect may be useful in the preservation of intestinal damage in cholestasis.en_US
dc.identifier.citationAra, C. Eşrefoğlu, M. Polat, A. Işık, B. Aladağ, M. Gül, M. Ay, S. Tekerekoğlu, M. S. Yılmaz, S. (2006). The effect of caffeic acid phenethyl ester on bacterial translocation and intestinal damage in cholestatic rats. Digestive Diseases and Sciences, 51(10), 1754–1760.en_US
dc.identifier.doi10.1007/s10620-006-9130-4en_US
dc.identifier.endpage1760en_US
dc.identifier.issn0163-2116
dc.identifier.issue10en_US
dc.identifier.startpage1754en_US
dc.identifier.urihttp://link.springer.com/10.1007/s10620-006-9130-4
dc.identifier.urihttps://hdl.handle.net/11616/7518
dc.identifier.volume51en_US
dc.language.isoenen_US
dc.publisherDigestive Diseases and Sciencesen_US
dc.relation.ispartofDigestive Diseases and Sciencesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCommon bile duct ligationen_US
dc.subjectBacterial translocationen_US
dc.subjectCaffeic acid phenethyl esteren_US
dc.subjectOxidative stressen_US
dc.subjectCytokinesen_US
dc.titleThe effect of caffeic acid phenethyl ester on bacterial translocation and intestinal damage in cholestatic ratsen_US
dc.typeArticleen_US

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