Protective effect of short-term thymoquinone administration on the central nervous system in cisplatin-induced neurotoxicity

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dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoriddurak, mehmet akif akif/0000-0003-0827-2708
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidDurhan, Merve/JOK-8847-2023
dc.authorwosiddurak, mehmet akif akif/ABI-1169-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorDurak, M. A.
dc.contributor.authorOzhan, O.
dc.contributor.authorYildiz, A.
dc.contributor.authorDurhan, M.
dc.contributor.authorVardi, N.
dc.contributor.authorCigremis, Y.
dc.contributor.authorParlakpinar, H.
dc.date.accessioned2024-08-04T20:53:04Z
dc.date.available2024-08-04T20:53:04Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: This study was performed to investigate the potential benefi- cial effects of thymoquinone (TQ) on brain tis-sue based on biochemical and histopathologi-cal analyses in cisplatin (CIS) treated rats with central nervous system (CNS) neurotoxicity. MATERIALS AND METHODS: The rats were randomly divided into 4 groups with 8 rats in each group (n:8). Group 1: (Control), saline was administered for 3 days at a volume of 0.5 ml per day intraperitoneal (i.p.). Group 2: (CIS Group), one dose of CIS was administered (7 mg/kg i.p.). Group 3: (TQ Group), TQ was giv-en at a dose of 5 mg/kg per day for 3 days (i.p.). Group 4: (CIS+TQ Group), one dose of 7 mg/ kg was initiated half an hour before adminis-tration of CIS and one dose of 5 mg/kg per day was administered TQ i.p. for 3 days. RESULTS: Malondialdehyde levels were found to be statistically significantly higher in the CIS group compared to the control group. Degenerative changes observed in the CIS+TQ group were found to be milder than in the CIS group. In the CIS+TQ group, a statistically sig-nificant decrease in the severity of caspase-3 immunoreactivity was found when compared to the CIS group. It was found that the sever-ity of neurofilament immunoreactivity moni- tored in neuronal extensions was similar in all groups. In the CIS+TQ group, the severity of tau protein's immunoreactivity was similar to that of the CIS-group.CONCLUSIONS: According to the results obtained in our study, beneficial effects were obtained in reducing neurotoxicity with short-term TQ application in rats treated with CIS treatment.en_US
dc.description.sponsorshipResearch Fund of In- onu University; [TSA-2020-2149]en_US
dc.description.sponsorshipFunding This work was supported by the Research Fund of In- onu University. Project Number: TSA-2020-2149.en_US
dc.identifier.endpage6943en_US
dc.identifier.issn1128-3602
dc.identifier.issue19en_US
dc.identifier.pmid36263573en_US
dc.identifier.scopus2-s2.0-85140261865en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage6935en_US
dc.identifier.urihttps://hdl.handle.net/11616/100952
dc.identifier.volume26en_US
dc.identifier.wosWOS:000877188200009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThymoquinoneen_US
dc.subjectCisplatinen_US
dc.subjectNeurotoxicityen_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.titleProtective effect of short-term thymoquinone administration on the central nervous system in cisplatin-induced neurotoxicityen_US
dc.typeArticleen_US

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