Strain and strain rate echocardiography in children with Wilson's disease

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dc.authoridKARAKURT, CEMŞIT/0000-0002-9246-8107
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridVarol, İlknur fatma/0000-0001-5212-218X
dc.authorwosidKARAKURT, CEMŞIT/ABE-2330-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidVarol, İlknur fatma/ABH-6387-2020
dc.contributor.authorKarakurt, Cemsit
dc.contributor.authorCelik, Serkan
dc.contributor.authorSelimoglu, Ayse
dc.contributor.authorVarol, Ilknur
dc.contributor.authorKarabiber, Hamza
dc.contributor.authorYologlu, Saim
dc.date.accessioned2024-08-04T20:42:52Z
dc.date.available2024-08-04T20:42:52Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This study aimed to evaluate strain and strain rate echocardiography in children with Wilson's disease to detect early cardiac dysfunction. Methods: In this study, 21 patients with Wilson's disease and a control group of 20 age-and gender-matched healthy children were included. All the patients and the control group were evaluated with two-dimensional (2D) and colour-coded conventional transthoracic echocardiography by the same paediatric cardiologist using the same echocardiography machine (Vivid E9, GE Healthcare, Norway) in standard precordial positions, according to the American Society of Echocardiography recommendations 2D strain and strain rate echocardiography were performed after the ECG probes of the echocardiography machine were adjusted for ECG monitoring. Longitudinal, transverse and radial strain, and strain rate were assessed from six basal and six mid-ventricular segments of the left ventricle, as recommended by the American Society of Echocardiography. Results: Left ventricular wall thickness, systolic and diastolic diameters, left ventricular diameters normalised to body surface area, end-systolic and end-diastolic volumes, cardiac output and cardiac index values were within normal limits and statistically similar in the patient and control groups (p > 0.05). Global strain and strain rate: the patient group had a statistically significant lower peak A longitudinal velocity of the left basal point and peak E longitudinal velocity of the left basal (VAbasR) point, and higher global peak A longitudinal/ circumferential strain rate (GSRa) compared to the corresponding values of the control group (p < 0.05). Radial strain and strain rate: end-systolic rotation [ROT (ES)] was statistically significantly lower in the patient group (p < 0.05). Longitudinal strain and strain rate: end-systolic longitudinal strain [SLSC (ES)] and positive peak transverse strain (STSR peak P) were statistically significantly lower in the patient group (p < 0.05). Segmental analysis showed that rotational strain measurement of the anterior and lateral segments of the patient group were statistically significantly lower than the corresponding values of the control group (p < 0.05). Segmental analysis showed statistically significantly lower values of end-systolic longitudinal strain [STSR (ES)] of the basal lateral (p < 0.05) and end-systolic longitudinal strain [SLSC (ES)] of the basal septal segment (p < 0.05) in the patient group. End-systolic longitudinal strain [SLSC (ES)] and positive peak transverse strain (STSR peak P) were statistically significantly lower in the patient group (p < 0.05). Segmental analysis showed statistically significantly lower values of end-systolic longitudinal strain [SLSC (ES)] of the mid-anterior and basal anterior segments (p < 0.05), end-systolic longitudinal strain [STSR (ES)] measurements of the posterior and mid-posterior segments, end-systolic longitudinal displacement [LDC (ES)] of the basal posterior, mid-posterior and mid-antero-septal segments in the patient group. Conclusion: Cardiac arrhythmias, cardiomyopathy and sudden cardiac death are rare complications but may be seen in children with Wilson's disease due to copper accumulation in the heart tissue. Strain and strain rate echocardiography is a relatively new and useful echocardiographic technique to evaluate cardiac function and cardiac deformation abnormalities. Our study showed that despite normal systolic function, patients with Wilson's disease showed diastolic dysfunction and regional deformation abnormalities, especially rotational strain and strain rate abnormalities.en_US
dc.identifier.doi10.5830/CVJA-2016-028
dc.identifier.endpage314en_US
dc.identifier.issn1995-1892
dc.identifier.issn1680-0745
dc.identifier.issue5en_US
dc.identifier.pmid27176875en_US
dc.identifier.scopus2-s2.0-85006121143en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage307en_US
dc.identifier.urihttps://doi.org/10.5830/CVJA-2016-028
dc.identifier.urihttps://hdl.handle.net/11616/97632
dc.identifier.volume27en_US
dc.identifier.wosWOS:000390890600008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClinics Cardive Publ Pty Ltden_US
dc.relation.ispartofCardiovascular Journal of Africaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject2D strainen_US
dc.subjectstrain rate echocardiographyen_US
dc.subjectspeckle trackingen_US
dc.subjectWilson's diseaseen_US
dc.titleStrain and strain rate echocardiography in children with Wilson's diseaseen_US
dc.typeArticleen_US

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