Comparative evaluation of toxicological effects and recovery patterns in zebrafish (Danio rerio) after exposure to phosalone-based and cypermethrin-based pesticides

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dc.authoridGüngördü, Abbas/0000-0001-7770-0660
dc.authorwosidOZMEN, MURAT/A-4874-2009
dc.authorwosidGüngördü, Abbas/A-3009-2015
dc.contributor.authorKorkmaz, Volkan
dc.contributor.authorGungordu, Abbas
dc.contributor.authorOzmen, Murat
dc.date.accessioned2024-08-04T20:45:23Z
dc.date.available2024-08-04T20:45:23Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study evaluated the toxic effects and recovery patterns in zebrafish (Danio redo) after exposure to phosalone-based (PBP) and cypermethrin-based (CBP) pesticides. Initially, the 96 h LC50 values of the pesticides were calculated as being 5.35 mu g of active ingredient (AI) L-1 for CBP and 217 mu g AI L-1 for PBP based on measured concentrations. Accordingly, experimental groups were exposed to three sublethal concentrations of pesticides for 96 h, separately, and then zebrafish were transferred to pesticide-free conditions for 10 and 20 days recovery periods. Biochemical markers were assessed including carboxylesterase (CaE), acetylcholinesterase (AChE), glutathione S-transferase (GST), lactate dehydrogenase, glutathione peroxidase, catalase, alanine and aspartate aminotransferase (ALT, AST) activities after the exposure and recovery periods. Also, the pesticide concentrations in test water were quantified by high-performance liquid chromatography (HPLC) analysis. Our results showed that AChE and CaE activities were significantly inhibited and GST was induced by both pesticides after 96 h exposure. For PBP exposure, the decreases for GST induction and CaE inhibition showed a partial recovery in pesticide-free conditions. However, the decreases in AChE activity for CBP exposure and insufficient increases in same enzyme activity for PBP exposure after 20 days in pesticide-free conditions indicated that the projected recovery period was not enough to the recovery of AChE activities and for the improvement of fish health.en_US
dc.description.sponsorshipInonu University Research Fund [2012/171]en_US
dc.description.sponsorshipThis study was supported by Inonu University Research Fund (project no.: 2012/171). The authors wish to thank the supporting institution.en_US
dc.identifier.doi10.1016/j.ecoenv.2018.05.055
dc.identifier.endpage272en_US
dc.identifier.issn0147-6513
dc.identifier.issn1090-2414
dc.identifier.pmid29852429en_US
dc.identifier.scopus2-s2.0-85052158442en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage265en_US
dc.identifier.urihttps://doi.org/10.1016/j.ecoenv.2018.05.055
dc.identifier.urihttps://hdl.handle.net/11616/98442
dc.identifier.volume160en_US
dc.identifier.wosWOS:000436216200032en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofEcotoxicology and Environmental Safetyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectZebrafishen_US
dc.subjectCypermethrinen_US
dc.subjectPhosaloneen_US
dc.subjectBiomarkeren_US
dc.subjectRecoveryen_US
dc.titleComparative evaluation of toxicological effects and recovery patterns in zebrafish (Danio rerio) after exposure to phosalone-based and cypermethrin-based pesticidesen_US
dc.typeArticleen_US

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