Synthesis, characterization and carbonic anhydrase inhibitory activity of novel benzothiazole derivatives

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dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486
dc.authoridKucukbay, Fatumetuzzehra/0000-0001-7784-4138
dc.authoridSupuran, Claudiu/0000-0003-4262-0323
dc.authoridBugday, Nesrin/0000-0002-3882-035X
dc.authorwosidkucukbay, fatumetuzzehra/X-5743-2019
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.contributor.authorKucukbay, F. Zehra
dc.contributor.authorBugday, Nesrin
dc.contributor.authorKucukbay, Hasan
dc.contributor.authorTanc, Muhammet
dc.contributor.authorSupuran, Claudiu T.
dc.date.accessioned2024-08-04T20:41:20Z
dc.date.available2024-08-04T20:41:20Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractN-protected amino acids were reacted with substituted benzothiazoles to give the corresponding N-protected amino acid-benzothiazole conjugates (60-89%). Their structures were confirmed by proton nuclear magnetic resonance (H-1 NMR), carbon-13 nuclear magnetic resonance (C-13 NMR), IR and elemental analysis. Their carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activities were determined against two cytosolic human isoforms (hCA I and hCA II), one membrane-associated (hCA IV) and one transmembrane (hCA XII) enzyme by a stopped-flow CO2 hydrase assay method. The new compounds showed rather weak, micromolar inhibitory activity against most of these enzymes.en_US
dc.description.sponsorshipInonu University, Turkey (BAPB); University Degli Studi di Firenze, Italyen_US
dc.description.sponsorshipWe thank Inonu University, Turkey (BAPB) and University Degli Studi di Firenze, Italy, for financial support.en_US
dc.identifier.doi10.3109/14756366.2015.1114931
dc.identifier.endpage1225en_US
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue6en_US
dc.identifier.pmid26598927en_US
dc.identifier.scopus2-s2.0-84947924827en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1221en_US
dc.identifier.urihttps://doi.org/10.3109/14756366.2015.1114931
dc.identifier.urihttps://hdl.handle.net/11616/97063
dc.identifier.volume31en_US
dc.identifier.wosWOS:000385270300045en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmino acid-benzothiazole conjugatesen_US
dc.subjectbenzothiazoleen_US
dc.subjectcarbonic anhydraseen_US
dc.titleSynthesis, characterization and carbonic anhydrase inhibitory activity of novel benzothiazole derivativesen_US
dc.typeArticleen_US

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