NEURO-PROTECTIVE EFFECTS OF CROCIN ON BRAIN AND CEREBELLUM TISSUES IN DIABETIC RATS

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dc.authoridÖner, Zülal/0000-0003-0459-1015
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridVardı, Nigar/0000-0003-0576-1696;
dc.authorwosidÖner, Zülal/T-2515-2019
dc.authorwosidAltinoz, Eyup/AAM-2378-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidElbe, Hulya/D-5261-2015
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorOner, Zulal
dc.contributor.authorElbe, Hulya
dc.contributor.authorVardi, Nigar
dc.date.accessioned2024-08-04T20:40:07Z
dc.date.available2024-08-04T20:40:07Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Increase in free oxygen radicals and the disruption of defense system make the neurons and astrocytes more sensitive against oxidative damage. Materials and Methods: Rats were divided into three groups containing 10, rats in each group namely: control (C) group, Diabetes Mellitus (DM) group, and Diabetes Mellitus + crocin (DM + crocin) group. Tissue samples were processed by routine histological and biochemical procedures. The sections were stained with Hematoxylen-eosin. Malondialdehyde (MDA), glutathione (GSH), blood glucose, HbA1c levels and xanthine oxidase (XO) activities were assayed. Results: The histological appearence of the cerebrum and cerebellum were normal in the control group. DM group showed some histopathological changes including congestion, perivascular and perineuronal edema in cerebrum. In DM + crocin group, histopathological changes in cerebrum and cerebellum markedly reduced. MDA level and XO activities increased significantly in DM group (P<0.01), but decreased significantly in DM + crocin group when compared to DM group (P<0.01). Blood glucose concentrations increased significantly (p<0.01) in DM group), but decreased significantly in DM + crocin group when compared with DM group (p<0.05). Blood HbA1c levels were normal in control group. But there were significant differences between control and DM groups (p<0.01). On the other hand, blood HbA1c levels decreased in DM + crocin group when compared with the DM group, but it was not statistically significant (p>0.05). Conclusion: Due to the fact that crocin has an antioxidant and anti-hyperglycemic effects, it can protect the brain and cerebellum tissue against the complications of oxidative stress.en_US
dc.identifier.doi10.4314/ajtcam.v11i6.2
dc.identifier.endpage39en_US
dc.identifier.issn0189-6016
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84923923737en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage33en_US
dc.identifier.urihttps://doi.org/10.4314/ajtcam.v11i6.2
dc.identifier.urihttps://hdl.handle.net/11616/96700
dc.identifier.volume11en_US
dc.identifier.wosWOS:000345923100002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAfrican Networks Ethnomedicinesen_US
dc.relation.ispartofAfrican Journal of Traditional Complementary and Alternative Medicinesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectoxidative stressen_US
dc.subjectcrocinen_US
dc.subjectbrainen_US
dc.subjectcerebellumen_US
dc.titleNEURO-PROTECTIVE EFFECTS OF CROCIN ON BRAIN AND CEREBELLUM TISSUES IN DIABETIC RATSen_US
dc.typeArticleen_US

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