Protective effects of melatonin and B-D-glucan against acetaminophen toxicity in rats

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dc.contributor.authorAydoğan, Mustafa Said
dc.contributor.authorPolat, Alaaddin
dc.contributor.authorVardı, Nigar
dc.contributor.authorErdoğan, M. Ali
dc.contributor.authorYücel, Aytaç
dc.contributor.authorYıldız, Azibe
dc.contributor.authorÖzgül, Ülkü
dc.date.accessioned2024-08-04T19:53:22Z
dc.date.available2024-08-04T19:53:22Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the possible protective effects of melatonin and ?-D-glucan against AA-induced liver injury in rats. Forty (Spraque-Dawley male) rats were randomly divided into 5 experimental groups: sham (S), acetaminophen only (AA, 900 mg/kg), melatonin (10 mg/kg) + AA (MLT), ?D-glucan (50 mg/kg) + AA (?), and melatonin + ?-D-glucan + AA (MLT+?) groups. All of the rats were killed on day 11 of the experiment. Histopathological changes and biochemical parameters including levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and liver tissue malondialdehyde (MDA), activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were determined to assess the liver function. MDA levels were the highest in the AA group whereas activities of SOD, CAT, and GPx in the liver tissue were found as lowest in this group. MDA activities were significantly lower in the MLT+? group than in the AA group. Only GPx activities in the MLT+? group were significantly higher than those in the MLT and ? groups. The serum AST and ALT levels were increased significantly following treatment with AA (p < 0.001). Pretreatment with the antioxidant compounds decreased AST levels significantly but again, the levels were still significantly higher than the sham levels (p < 0.001). There were no statistically significant differences in the microscopic damage between the S, MLT, ?, and MLT+? groups (p > 0.05). We concluded that combination of melatonin and ?-D-glucan may be attributed to scavenging free radicals and stimulating the antioxidant enzymes.en_US
dc.identifier.endpage543en_US
dc.identifier.issn2147-0634
dc.identifier.issue2en_US
dc.identifier.startpage539en_US
dc.identifier.trdizinid282574en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/282574
dc.identifier.urihttps://hdl.handle.net/11616/89724
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleProtective effects of melatonin and B-D-glucan against acetaminophen toxicity in ratsen_US
dc.typeArticleen_US

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