Synthesis, characterization, crystal structure and bioactivity properties of the benzimidazole-functionalized PEPPSI type of Pd(II)NHC complexes

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dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authoridIzmirli, Merve/0000-0002-3935-2674
dc.authorwosidBarut Celepci, Duygu/M-6189-2017
dc.authorwosidTaslimi, Parham/AAL-2788-2020
dc.authorwosidGulcin, ilhami/F-1428-2014
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.contributor.authorDasgin, Semra
dc.contributor.authorGok, Yetkin
dc.contributor.authorCelepci, Duygu Barut
dc.contributor.authorTaslimi, Parham
dc.contributor.authorIzmirli, Merve
dc.contributor.authorAktas, Aydin
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-08-04T20:49:01Z
dc.date.available2024-08-04T20:49:01Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHerein, six new benzimidazole-functionalized Pd-based complexes bearing N-propylphthalimide group were synthesized. These new PEPPSI type of Pd(II)NHC complexes (PEPPSI: Pyridine Enhanced Precatalyst Preparation, Stabilization and Initiation) were prepared from the N-propylphthalimide substituted benzimidazolium salts, palladium chloride (PdCl2) and 3-chloropyridine. The structures of all (NHC)PdX2(3-chloropyridine) complexes have been clearly characterized by using NMR (H-1 and C-13), FTIR spectroscopic method, and elemental analysis techniques. Also, the structures of three of the (NHC)PdX2(3-chloropyridine) complexes were confirmed by single-crystal X-ray diffraction. Also, novel N-propylphthalimide-substituted (NHC)PdX 2 (3-chloropyridine) complexes effectively inhibited acetylcholinesterase (AChE), with Ki values in the range of 0.54 +/- 0.10 to 3.01 +/- 0.63 mu M. For butyryl-cholinesterase (BChE) was obtained with Ki values in the range of 0.82 +/- 0.11 to 5.03 +/- 0.86 mu M. For alpha-glycosidase (alpha-Gly) the most effective Ki values of 1c, 1d, and 1b were with Ki values of 23.83 +/- 5.98, 26.04 +/- 7.11, and 30.61 +/- 3.85 mu M, respectively. All novel N-propylphthalimide-substituted PEPPSI complexes and control compounds had almost similar inhibition profiles. (C) 2020 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipInonu University (Turkey) Research Fund [IUBAP: 2015/10]; Dokuz Eylul University [2010.KB.FEN.13]en_US
dc.description.sponsorshipThe authors acknowledge that this work was financially supported by Inonu University (Turkey) Research Fund (IUBAP: 2015/10). The authors acknowledge Inonu University Scientific and Technology Center for the elemental analyses of the compounds. The authors acknowledge the Inonu University Faculty of Science Department of Chemistry for the NMR and FTIR characterization of compounds. The authors acknowledge Dokuz Eylul University for the use of the Rigaku Oxford Xcalibur Eos Diffractometer (purchased under University Research Grant No: 2010.KB.FEN.13).en_US
dc.identifier.doi10.1016/j.molstruc.2020.129442
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85092902005en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2020.129442
dc.identifier.urihttps://hdl.handle.net/11616/99595
dc.identifier.volume1228en_US
dc.identifier.wosWOS:000609158100004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectPEPPSI complexen_US
dc.subjectX-ray diffractionen_US
dc.subjectalpha-Glycosidaseen_US
dc.titleSynthesis, characterization, crystal structure and bioactivity properties of the benzimidazole-functionalized PEPPSI type of Pd(II)NHC complexesen_US
dc.typeArticleen_US

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