Effects of cranberry (Vaccinum macrocarpon) supplementation on iron status and inflammatory markers in rowers

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dc.authoridkafkas, muhammed emin/0000-0002-3962-6428
dc.authoridBasta, Piotr/0000-0003-2439-3315
dc.authoridSkarpanska - Stejnborn, Anna/0000-0002-7795-3550
dc.authorwosidkafkas, muhammed emin/S-4922-2019
dc.authorwosidKAFKAS, MUHAMMED EMİN/AAH-9027-2019
dc.contributor.authorSkarpanska-Stejnborn, Anna
dc.contributor.authorBasta, Piotr
dc.contributor.authorTrzeciak, Jerzy
dc.contributor.authorMichalska, Alicja
dc.contributor.authorKafkas, M. Emin
dc.contributor.authorWoitas-Slubowska, Donata
dc.date.accessioned2024-08-04T20:44:16Z
dc.date.available2024-08-04T20:44:16Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to analyze the effect of supplementation with cranberry (Vaccinum macrocarpon) on the levels of pro-inflammatory cytokines, hepcidin and selected markers of iron metabolism in rowers subjected to exhaustive exercise. Methods: This double-blind study included 16 members of the Polish Rowing Team. The subjects were randomly assigned to the supplemented group (n = 9), receiving 1200 mg of cranberry extract for 6 weeks, or to the placebo group (n = 7). The participants performed a 2000-m test on a rowing ergometer at the beginning and at the end of the preparatory camp. Blood samples were obtained from the antecubital vein prior to each exercise test, one minute after completing the test, and after a 24-h recovery period. The levels of hepcidin, interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), ferritin, iron, soluble transferrin receptor (sTfR) and myoglobin were determined, along with total iron-binding capacity (TIBC), unbound iron-binding capacity (UIBC) and total antioxidant capacity (TAC). Results: Both prior and after the supplementation, a significant post-exercise increase in the concentration of IL-6 was observed in both groups. At the end of the study period, cranberry-supplemented athletes presented with significantly higher resting, post-exercise and post-recovery levels of TAC than the controls. However, a significant exercise-induced increase in the concentrations of TNF-alpha, myoglobin and hepcidin was observed solely in the control group. Conclusion: Supplementation with cranberry extract contributed to a significant strengthening of antioxidant potential in individuals exposed to strenuous physical exercise. However, supplementation did not exert direct effects on other analyzed parameters: inflammatory markers and indices of iron metabolism (TNF-alpha, hepcidin and myoglobin).en_US
dc.description.sponsorshipPolish Ministry of Science and Higher Education [N N404 256240]en_US
dc.description.sponsorshipThis study was supported by a grant from the Polish Ministry of Science and Higher Education (project no. N N404 256240).en_US
dc.identifier.doi10.1186/s12970-017-0165-z
dc.identifier.issn1550-2783
dc.identifier.pmid28261001en_US
dc.identifier.scopus2-s2.0-85041270571en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s12970-017-0165-z
dc.identifier.urihttps://hdl.handle.net/11616/98136
dc.identifier.volume14en_US
dc.identifier.wosWOS:000397043200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBiomed Central Ltden_US
dc.relation.ispartofJournal of The International Society of Sports Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCranberryen_US
dc.subjectSupplementationen_US
dc.subjectStrenuous exerciseen_US
dc.subjectInflammationen_US
dc.titleEffects of cranberry (Vaccinum macrocarpon) supplementation on iron status and inflammatory markers in rowersen_US
dc.typeArticleen_US

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