Effects of intracerebroventricular administration of irisin on the hypothalamus-pituitary-gonadal axis in male rats

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dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridErden, Yavuz/0000-0002-2807-6096
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidErden, Yavuz/IZE-2291-2023
dc.contributor.authorTekin, Suat
dc.contributor.authorBeytur, Ali
dc.contributor.authorErden, Yavuz
dc.contributor.authorBeytur, Asiye
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorVardi, Nigar
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2024-08-04T20:45:30Z
dc.date.available2024-08-04T20:45:30Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIrisin is a product of fibronectin type III domain-containing protein 5 (FNDC5) and plays an important role in energy homeostasis. In this study, we aimed to determine effects of intracerebroventricular administration of irisin on the hypothalamus-pituitary-gonadal axis by molecular, biochemical, and morphological findings. Fourty male Wistar-Albino rats were used and divided into four groups including control, sham (vehicle), 10, and 100 nM irisin infused groups (n = 10). Hypothalamic gonadotropin releasing hormone (GnRH) level and serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone levels were determined. Testicular tissue histology and spermiogram analysis were also performed. Both irisin concentrations significantly reduced hypothalamic GnRH messenger RNA (mRNA) and protein levels (p < 0.05). It was found that serum LH, FSH, and testosterone levels and Sertoli and Leydig cell numbers were decreased by irisin administration (p < 0.05). In addition, irisin administration reduced sperm density and mobility (p < 0.05). However, it did not cause any change in testicular and epididymis weights and tubular diameter. Our results reveal that irisin can play a role in the central regulation of reproductive behavior and also reduces testosterone levels by suppressing LH and FSH secretion. These results suggest that the discovery of irisin receptor antagonists may be beneficial in the treatment of infertility.en_US
dc.description.sponsorshipScientific & Technological Research Council of Turkey (TUBITAK) [214S567]en_US
dc.description.sponsorshipThe Scientific & Technological Research Council of Turkey (TUBITAK), Grant/Award Number: 214S567en_US
dc.identifier.doi10.1002/jcp.27541
dc.identifier.endpage8824en_US
dc.identifier.issn0021-9541
dc.identifier.issn1097-4652
dc.identifier.issue6en_US
dc.identifier.pmid30317602en_US
dc.identifier.scopus2-s2.0-85054902916en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage8815en_US
dc.identifier.urihttps://doi.org/10.1002/jcp.27541
dc.identifier.urihttps://hdl.handle.net/11616/98496
dc.identifier.volume234en_US
dc.identifier.wosWOS:000459314500098en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cellular Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFSHen_US
dc.subjectGnRHen_US
dc.subjectirisinen_US
dc.subjectLHen_US
dc.subjecttestosteroneen_US
dc.titleEffects of intracerebroventricular administration of irisin on the hypothalamus-pituitary-gonadal axis in male ratsen_US
dc.typeArticleen_US

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