Candidemia in adult intensive care units: Analysis of a 4 year process in a tertiary hospital in Turkey

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dc.contributor.authorErdoğan, Esra
dc.contributor.authorErdoğan, Mehmet Mustafa
dc.contributor.authorDelen, Leman Acun
dc.date.accessioned2024-08-04T19:42:38Z
dc.date.available2024-08-04T19:42:38Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Candidemia are one of the most important causes of mortality and morbidity in inpatients, and their importance is increasingwith the increasing number of immunosuppressive patients and the widespread use of invasive procedures and broad spectrumantibiotics in recent years. In our study, we aimed to identify Candida species isolated from blood cultures and to determine theantifungal susceptibility rates of adult patients who were hospitalized in Malatya Education and Research Hospital Intensive CareUnits between July 2015 and July 2019, and had Candida growth in at least one of their blood cultures.Materials and Methods: The blood cultures isolated from adult intensive care units patients and sent to the Microbiology Laboratoryof our hospital over the four years, were examined retrospectively. Species distribution and antifungal susceptibility were determinedusing VITEK 2 Compact System (BioMerieux, France).Results: Of the 123 clinical samples, 59 (48%) were C. albicans, 21 (17.1%) were C. parapsilosis, 18 (14.6%) were C. tropicalis, 12(9.8%) were C. glabrata, 5 (4.1%) were C. kefyr, 2 (1.6%) were C. krusei, 2 (1.6%) were C. lipoliytica, 2 (1.6%) were C. lusitaniae, 1 (0.8%)was C. dubliniensis and 1 (0.8%) was C. pelliculosa. 96.5% of C. glabrata strains were found to be susceptible to amphotericin-B,93.1% to fluconazole, 98.3% to voriconazole, 93.5% to caspofungin, 91.4% to micafungin and 96.7% to flucytosine. 98.1% of nonalbicansCandida (NAC) strains were found to be susceptible to amphotericin-B, 74.6% to fluconazole, 90.7% to voriconazole, 78.4%to caspofungin, 80% to micafungin and 100% to flucytosine.Conclusion: The highest resistance to antifungals was found in C. glabrata and the highest susceptibility was observed in C. tropicalis.In order to develop effective and accurate infection control strategies and reduce mortality and morbidity, it is important to know thedistribution and susceptibility of infectious agents, especially in critical patients in intensive care units.en_US
dc.identifier.doi10.5455/annalsmedres.2019.11.756
dc.identifier.endpage2973en_US
dc.identifier.issn2636-7688
dc.identifier.issue11en_US
dc.identifier.startpage2968en_US
dc.identifier.trdizinid421163en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2019.11.756
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/421163
dc.identifier.urihttps://hdl.handle.net/11616/88525
dc.identifier.volume27en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleCandidemia in adult intensive care units: Analysis of a 4 year process in a tertiary hospital in Turkeyen_US
dc.typeArticleen_US

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