Obesity and Nutritional Vulnerability in long COVID: A Neuroinflammatory and Cognitive Perspective

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dc.contributor.authorBozkir, Cigdem
dc.contributor.authorKartal, Tugce
dc.contributor.authorHokelek, Busra
dc.date.accessioned2026-04-04T13:35:17Z
dc.date.available2026-04-04T13:35:17Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractPurpose of ReviewTo examine the interplay between obesity, nutritional vulnerability, and long COVID, with a particular focus on neuroinflammatory and cognitive outcomes. This review synthesizes emerging evidence on shared pathophysiological pathways and evaluates the therapeutic potential of dietary and weight management strategies.Recent FindingsCognitive symptoms such as brain fog and memory deficits are among the most persistent and disabling features of long COVID. Obesity is associated with more severe manifestations through pathways involving chronic systemic inflammation, compromised blood-brain barrier integrity, and neuroimmune dysregulation. Concurrently, malnutrition and poor diet quality including low intake of antioxidants, omega-3 fatty acids, and micronutrients may impair neuroplasticity and delay recovery. Interventions such as Mediterranean and ketogenic dietary patterns, as well as structured weight loss programs, show promise in reducing inflammation and improving cognitive outcomes.SummaryObesity and suboptimal nutritional status amplify the neurocognitive burden of long COVID through shared pathophysiological mechanisms. Integrated care models that incorporate metabolic screening, nutritional assessment, and individualized dietary interventions may improve recovery trajectories. Public health strategies that address food quality, obesity prevention, and equitable access to nutrition care are essential for long-term resilience in the post-COVID era.
dc.description.sponsorshipInonu University
dc.description.sponsorshipOpen access funding provided by the Scientific and Technological Research Council of Turkiye (TUB & Idot;TAK).
dc.identifier.doi10.1007/s13668-026-00730-y
dc.identifier.issn2161-3311
dc.identifier.issue1
dc.identifier.orcid0000-0002-1103-6290
dc.identifier.pmid41543809
dc.identifier.scopus2-s2.0-105027705250
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s13668-026-00730-y
dc.identifier.urihttps://hdl.handle.net/11616/109753
dc.identifier.volume15
dc.identifier.wosWOS:001662330200002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofCurrent Nutrition Reports
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectLong COVID
dc.subjectPASC
dc.subjectObesity
dc.subjectBrain fog
dc.subjectCognitive dysfunction
dc.titleObesity and Nutritional Vulnerability in long COVID: A Neuroinflammatory and Cognitive Perspective
dc.typeReview

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