Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidElbe, Hulya/D-5261-2015
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorTaslidere, Elif
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorElbe, Hulya
dc.contributor.authorCetin, Asli
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:38:03Z
dc.date.available2024-08-04T20:38:03Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Exposure to carbon tetrachloride (CCl4), a well-known toxicant, causes tissue damage by inducing oxidative stress via formation of free radicals. The fundamental structure of the organs of rats and humans is similar, so administration of CCl4 to rats is an accepted experimental model to produce oxidative damage to various tissues including pulmonary tissue. In this study, we evaluated the protective capacity of melatonin and quercetin against CCl4-induced oxidative lung damage in rats. Material-Metods: Rats were divided into five groups each containing seven rats as follows: Control group, Olive oil group CCl4 group, CCl4+Melatonin, and CCl4+Quercetin group. The tissue samples were processed by routine histological and biochemical procedures. Sections were stained with Hematoxylin-eosin and Masson's trichrome. Histopathologic damage score was calculated. Malondialdehyde (MDA) and glutathione (GSH) levels and catalase (CAT) activities were assayed. Results: The lung sections of control groups showed normal histological characteristics. Fibrosis, interstitial hemorrhage, epithelial desquamation in bronchiole and alveoli, intra-alveolar edema, leukocyte, and macrophage infiltration were observed in lung sections of rats exposed to CCl4 alone. The findings were reduced in the treatments groups. The MDA level in the CCl4 group were significantly higher than in the other groups (p < .001), and the CAT and GSH levels in the CCl4+Mel and CCl4+Quer groups were significantly higher than in the CCl4 group (p < .05). Conclusion: In conclusion, we suggest that agents with antioxidant properties such as melatonin and quercetin may have positive effects in the treatment of pulmonary diseases characterized by especially edema, inflammation, and fibrosis.en_US
dc.identifier.doi10.3109/01902148.2013.866181
dc.identifier.endpage65en_US
dc.identifier.issn0190-2148
dc.identifier.issn1521-0499
dc.identifier.issue2en_US
dc.identifier.pmid24447267en_US
dc.identifier.scopus2-s2.0-84894125705en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://doi.org/10.3109/01902148.2013.866181
dc.identifier.urihttps://hdl.handle.net/11616/96351
dc.identifier.volume40en_US
dc.identifier.wosWOS:000331834400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofExperimental Lung Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcarbon tetrachlorideen_US
dc.subjectlungen_US
dc.subjectmelatoninen_US
dc.subjectquercetinen_US
dc.subjectraten_US
dc.titleProtective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in ratsen_US
dc.typeArticleen_US

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