EEG and MRI findings and their relation with intellectual disability in pervasive developmental disorders

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dc.authoridÖzcan, Özlem/0000-0003-3267-2648;
dc.authorwosidÖzcan, Özlem/ABH-9167-2020
dc.authorwosidaysev, Ayla/B-9696-2013
dc.contributor.authorUnal, Ozlem
dc.contributor.authorOzcan, Ozlem
dc.contributor.authorOner, Ozguer
dc.contributor.authorAkcakin, Melda
dc.contributor.authorAysev, Ayla
dc.contributor.authorDeda, Guelhis
dc.date.accessioned2024-08-04T20:31:17Z
dc.date.available2024-08-04T20:31:17Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. The diagnostic category pervasive developmental disorders (PDDs) refer to a group of five disorders: autism, Rett syndrome, childhood disintegrative disorder, Asperger syndrome, and pervasive developmental disorder not otherwise specified (PDD-NOS). EEG abnormalities and seizures are considered much frequent in autistic subjects with comorbid intellectual disability (ID). In this study, we aimed to evaluate the EEG and MRI findings and their relation with ID in pervasive developmental disorder. Methods: A retrospective, cross-sectional and non-experimental study was performed. Subjects included 81 patients diagnosed with autism or PDD-NOS according to the DSM-IV criteria. The age range of the patients was 2-15 years (mean 6.6 years, SD 3.0). Among them, 21 (25.9%) were girls and 60 boys (74.1%). Results: Patients with severe ID had a higher rate of EEG abnormalities (P=0.03) than patients without ID as well as patients with mild or moderate ID. The association remained significant after the structural MRI abnormalities were controlled (P=0.04). The severity of ID was not associated with abnormal MRI. The most frequent EEG and MRI abnormalities were active epileptic anomaly/paroxysmal abnormality and cerebral atrophy/periventricular leukomalacia, respectively. Almost a third of the EEG abnormalities were associated with temporal cortex and adjacent cortical structures. Conclusions: Consistent with previous studies, almost a fourth of the patients in this relatively large sample of patients with pervasive developmental disorders had EEG and/or MRI abnormalities. EEG results indicate that temporal cortex may play a significant role in pervasive developmental disorders.en_US
dc.identifier.doi10.1007/s12519-009-0037-y
dc.identifier.endpage200en_US
dc.identifier.issn1708-8569
dc.identifier.issn1867-0687
dc.identifier.issue3en_US
dc.identifier.pmid19693463en_US
dc.identifier.scopus2-s2.0-69249179563en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage196en_US
dc.identifier.urihttps://doi.org/10.1007/s12519-009-0037-y
dc.identifier.urihttps://hdl.handle.net/11616/94858
dc.identifier.volume5en_US
dc.identifier.wosWOS:000268821600007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherZhejiang Univ Pressen_US
dc.relation.ispartofWorld Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectautismen_US
dc.subjectelectroencephalographyen_US
dc.subjectmagnetic resonance imagingen_US
dc.subjectpervasive developmental disordersen_US
dc.titleEEG and MRI findings and their relation with intellectual disability in pervasive developmental disordersen_US
dc.typeArticleen_US

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